Molecular structure of Venturicidin B, CAS Number: 33538-72-6
Venturicidin B (CAS 33538-72-6)
Alternate Names:
Aabomycin A2
Application:
Venturicidin B is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector
CAS Number:
33538-72-6
Purity:
>95%
Molecular Weight:
706.9
Molecular Formula:
C40H66O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Venturicidin B is an antibiotic that has been reported to be a potent inhibitor of the ATP5 (mitochondrial ATP synthase complex). This compound interferes with the F0 portion of membrane-located K+ and H+-ATPase channels and decreases probability of the channels from opening. By blocking proton transfer across the membrane, Venuricidin B causes a halt in ATP synthase activity.
Venturicidin B (CAS 33538-72-6) References
- Studies on energy-linked reactions: isolation and properties of mitochondrial venturicidin-resistant mutants of Saccharomyces cerevisiae. | Griffiths, DE., et al. 1975. Eur J Biochem. 51: 393-402. PMID: 238835
- Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2. | Shaaban, KA., et al. 2014. J Antibiot (Tokyo). 67: 223-30. PMID: 24252813
- Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance. | Galanis, M., et al. 1989. FEBS Lett. 249: 333-6. PMID: 2661266
- Complex effects of macrolide venturicidins on bacterial F-ATPases likely contribute to their action as antibiotic adjuvants. | Milgrom, YM. and Duncan, TM. 2021. Sci Rep. 11: 13631. PMID: 34211053
- Antibiotic inhibitors of mitochondrial energy transfer. | Lardy, HA. 1980. Pharmacol Ther. 11: 649-60. PMID: 7003608
- Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers. | Miedema, H., et al. 1994. Biochem Biophys Res Commun. 203: 1005-12. PMID: 8093018
- Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. | Matsuno-Yagi, A. and Hatefi, Y. 1993. J Biol Chem. 268: 6168-73. PMID: 8454592
Inhibitor of:
ATP5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Venturicidin B, 250 µg | sc-202381 | 250 µg | $270.00 |