Molecular structure of Venturicidin A, CAS Number: 33538-71-5
Venturicidin A (CAS 33538-71-5)
Alternate Names:
Aabomycin A1
Application:
Venturicidin A is an antibiotic and potent inhibitor of mitochondrial ATP synthase
CAS Number:
33538-71-5
Purity:
>95%
Molecular Weight:
750.0
Molecular Formula:
C41H67NO11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Venturicidin A, an antibiotic and antifungal compound, has been noted to be a potential inhibitor of E. coli H+-ATPase. Experiments suggest that this compound strongly inhibits ATP-driven proton transport and ATP hydrolysis. More detailed studies show that Venturicidin A acts on the membrane sector F0. Purified bovine F0 has been reported to cause voltage sensitive K+ channels. Venturicidin A demonstrates the ability to drastically decrease the open probability of the channel. Venturicidin A is an inhibitor of ATP5.
Venturicidin A (CAS 33538-71-5) References
- IB-00208, a new cytotoxic polycyclic xanthone produced by a marine-derived Actinomadura. I. Isolation of the strain, taxonomy and biological activites. | Malet-Cascón, L., et al. 2003. J Antibiot (Tokyo). 56: 219-25. PMID: 12760677
- Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. | Otoguro, K., et al. 2008. J Antibiot (Tokyo). 61: 372-8. PMID: 18667785
- Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2. | Shaaban, KA., et al. 2014. J Antibiot (Tokyo). 67: 223-30. PMID: 24252813
- Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin. | Perlin, DS., et al. 1985. Biochim Biophys Acta. 807: 238-44. PMID: 2859888
- Time-resolved ATP measurements during vesicle respiration. | Lin, J., et al. 2019. Talanta. 205: 120083. PMID: 31450430
- Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics. | Yarlagadda, V., et al. 2020. Sci Rep. 10: 8134. PMID: 32424122
- Discovery of Venturicidin Congeners and Identification of the Biosynthetic Gene Cluster from Streptomyces sp. NRRL S-4. | Li, H., et al. 2021. J Nat Prod. 84: 110-119. PMID: 33356258
- Complete 1 H and 13 C NMR spectral assignment of venturicidin A by 2D NMR spectroscopy. | Gogoll, A. and Tanner, D. 1989. Magn Reson Chem. 27: 863-871. PMID: 34034427
- Complex effects of macrolide venturicidins on bacterial F-ATPases likely contribute to their action as antibiotic adjuvants. | Milgrom, YM. and Duncan, TM. 2021. Sci Rep. 11: 13631. PMID: 34211053
- Structural insights into the substrate binding sites of O-carbamoyltransferase VtdB from Streptomyces sp. NO1W98. | Rao, DF., et al. 2023. Biochem Biophys Res Commun. 659: 40-45. PMID: 37031593
- Irumamycin, a new antibiotic active against phytopathogenic fungi. | Omura, S., et al. 1982. J Antibiot (Tokyo). 35: 256-7. PMID: 7076572
- Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers. | Miedema, H., et al. 1994. Biochem Biophys Res Commun. 203: 1005-12. PMID: 8093018
- Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. | Matsuno-Yagi, A. and Hatefi, Y. 1993. J Biol Chem. 268: 6168-73. PMID: 8454592
Inhibitor of:
ATP10B, ATP5, ATP5B, ATP5G3, ATP5J2, ATPAF1, F1-ATPase, Mitochondrial ATP synthase (ATP5G), MP68, OSCP, and Tim22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Venturicidin A, 1 mg | sc-202380 | 1 mg | $203.00 | |||
Venturicidin A, 5 mg | sc-202380A | 5 mg | $465.00 |