Date published: 2026-4-24

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Venlafaxine N-Oxide (CAS 1094598-37-4)

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Alternate Names:
1-[2-(Dimethyloxidoamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol
CAS Number:
1094598-37-4
Molecular Weight:
293.40
Molecular Formula:
C17H27NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Venlafaxine n-oxide has garnered attention as a prospective biomarker for monitoring Venlafaxine metabolism. By impeding the reuptake of serotonin and norepinephrine in the brain, Venlafaxine n-oxide operates to heighten the levels of these neurotransmitters within the synaptic cleft. Consequently, neurotransmission intensifies, culminating in an amelioration of mood and anxiety symptoms. Furthermore, the investigation of Venlafaxine n-oxide′s potential as a biomarker represents a valuable avenue for comprehending Venlafaxine′s metabolic pathways.


Venlafaxine N-Oxide (CAS 1094598-37-4) References

  1. Evaluation of a full-scale wastewater treatment plant upgraded with ozonation and biological post-treatments: Abatement of micropollutants, formation of transformation products and oxidation by-products.  |  Bourgin, M., et al. 2018. Water Res. 129: 486-498. PMID: 29190578
  2. Non-target screening to trace ozonation transformation products in a wastewater treatment train including different post-treatments.  |  Schollée, JE., et al. 2018. Water Res. 142: 267-278. PMID: 29890475
  3. Enantiomeric Fractionation during Biotransformation of Chiral Pharmaceuticals in Recirculating Water-Sediment Test Flumes.  |  Mechelke, J., et al. 2020. Environ Sci Technol. 54: 7291-7301. PMID: 32388979
  4. Ozone dose dependent formation and removal of ozonation products of pharmaceuticals in pilot and full-scale municipal wastewater treatment plants.  |  Kharel, S., et al. 2020. Sci Total Environ. 731: 139064. PMID: 32413657
  5. MBBRs as post-treatment to ozonation: Degradation of transformation products and ozone-resistant micropollutants.  |  Edefell, E., et al. 2021. Sci Total Environ. 754: 142103. PMID: 32920394
  6. Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors.  |  Eh-Haj, BM. 2021. Molecules. 26: PMID: 33805491
  7. Further transformation of the primary ozonation products of tramadol- and venlafaxine N-oxide: Mechanistic and structural considerations.  |  Kharel, S., et al. 2022. Sci Total Environ. 845: 157259. PMID: 35817117
  8. Multiclass target analysis of contaminants of emerging concern including transformation products, soil bioavailability assessment and retrospective screening as tools to evaluate risks associated with reclaimed water reuse.  |  Beretsou, VG., et al. 2022. Sci Total Environ. 852: 158391. PMID: 36049679
  9. Effects of substrate loading on co-metabolic transformation pathways and removal rates of pharmaceuticals in biofilm reactors.  |  Liang, C., et al. 2022. Sci Total Environ. 853: 158607. PMID: 36089036
  10. Persistence of N-oxides transformation products of tertiary amine drugs at lab and field studies.  |  Manasfi, R., et al. 2022. Chemosphere. 309: 136661. PMID: 36191765
  11. Stable isotope labeling for detection of ozonation byproducts in effluent organic matter with FT-ICR-MS.  |  Jennings, EK., et al. 2023. Water Res. 229: 119477. PMID: 36528925
  12. Isotopically labeled ozone: A new approach to elucidate the formation of ozonation products.  |  Sierra-Olea, M., et al. 2023. Water Res. 233: 119740. PMID: 36822109
  13. Ozonation of Gabapentin in Water─Investigating Reaction Kinetics and Transformation Mechanisms of a Primary Amine Using Isotopically Labeled Ozone.  |  Bein, E., et al. 2023. Environ Sci Technol.. PMID: 37099017

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Venlafaxine N-Oxide, 50 mg

sc-475595
50 mg
$388.00