Molecular structure of Venlafaxine Hydrochloride, CAS Number: 99300-78-4
Venlafaxine Hydrochloride (CAS 99300-78-4)
See product citations (3)
Application:
Venlafaxine Hydrochloride is an inhibitor of ST and SLC6A2
CAS Number:
99300-78-4
Purity:
98%
Molecular Weight:
313.9
Molecular Formula:
C17H27NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Venlafaxine Hydrochloride is a dual ST and SLC6A2 (serotonin and noradrenalin re-uptake) inhibitor that displays ~ 30-fold higher affinity for ST (SERT) (Ki = 82 nm) than SLC6A2 (NET) (Ki = 2480 nM). It exerts minimal effect on other neurotransmitter systems. It is primarily utilized in research focused on neurotransmitter systems due to its interaction with serotonin and norepinephrine transporters. Some research suggests that venlafaxine hydrochloride may have electrophysiological effects on the heart′s fast conducting cells. Research conducted on isolated guinea pig ventricular myocytes demonstrated that venlafaxine hydrochloride inhibits the fast inward sodium current in a concentration-dependent manner, with an estimated IC50 of 8 µM.
Venlafaxine Hydrochloride (CAS 99300-78-4) References
- Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. | Bymaster, FP., et al. 2001. Neuropsychopharmacology. 25: 871-80. PMID: 11750180
- SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. | Stahl, SM., et al. 2005. CNS Spectr. 10: 732-47. PMID: 16142213
- Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers. | Blier, P., et al. 2007. Int J Neuropsychopharmacol. 10: 41-50. PMID: 16690005
- CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. | Shams, ME., et al. 2006. J Clin Pharm Ther. 31: 493-502. PMID: 16958828
- In vivo effect of venlafaxine on locus coeruleus neurons: role of opioid, alpha(2)-adrenergic, and 5-hydroxytryptamine(1A) receptors. | Berrocoso, E. and Mico, JA. 2007. J Pharmacol Exp Ther. 322: 101-7. PMID: 17431134
- Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique. | Khanfar, M., et al. 2014. Pharm Dev Technol. 19: 103-15. PMID: 23347382
- Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method. | Bernardi, LS., et al. 2013. Talanta. 117: 189-95. PMID: 24209329
- Cytogenotoxic effects of venlafaxine hydrochloride on cultured human peripheral blood lymphocytes. | Ayabaktı, S. and Yavuz Kocaman, A. 2020. Drug Chem Toxicol. 43: 192-199. PMID: 30025480
- Selenium attenuates venlafaxine hydrochloride-induced testicular damage in mice via modulating oxidative stress and apoptosis. | Kaur, S., et al. 2021. Andrologia. 53: e14050. PMID: 33733493
- Enantioseparation of five racemic N-alkyl drugs by reverse phase HPLC using sulfobutylether-β-cyclodextrin as a chiral mobile phase additive. | Chen, B., et al. 2022. J Sep Sci. 45: 1847-1855. PMID: 35322921
- Resonance Rayleigh scattering approach based on association complex formation with erythrosine B for determination of venlafaxine, application to the dosage form and spiked human plasma. | Mohammed, BS., et al. 2022. Luminescence. 37: 1215-1222. PMID: 35582967
- Venlafaxine. A review of its pharmacology and therapeutic potential in depression. | Holliday, SM. and Benfield, P. 1995. Drugs. 49: 280-94. PMID: 7729333
- Venlafaxine: a new antidepressant drug. | Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
Inhibitor of:
SLC6A2, and ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Venlafaxine Hydrochloride, 10 mg | sc-201102 | 10 mg | $135.00 | |||
Venlafaxine Hydrochloride, 50 mg | sc-201102A | 50 mg | $600.00 |