Molecular structure of VEGFR2 kinase inhibitor IV, CAS Number: 216661-57-3
VEGFR2 kinase inhibitor IV (CAS 216661-57-3)
Alternate Names:
3-(3-Thienyl)-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine
Application:
VEGFR2 kinase inhibitor IV is an ATP-competitive VEGFR-2 (Flk-1) and PDGFR-beta inhibitor
CAS Number:
216661-57-3
Purity:
≥95%
Molecular Weight:
307.37
Molecular Formula:
C17H13N3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A 3,6-diaryl substituted pyrazolopyrimidine that acts as a potent, ATP-competitive inhibitor of VEGFR-2 (KDR/Flk-1; IC50 = 19 nM). Displays ~2-fold greater selectivity for VEGFR-2 over PDGFRb (IC50 = 34 nM) and 10-fold greater selectivity over VEGFR-1 (Flt-1) and VEGFR-3 (Flt-4; IC50 = 190 nM) tyrosine kinase activity. Does not inhibit FGFR-1 or Src kinase activity (IC50 > 1.9 µM). Shown to inhibit VEGF-stimulated mitogenesis in human umbilical vein endothelial cells (IC50 = 387 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.
Inhibitor of:
Flk-1, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VEGFR2 kinase inhibitor IV, 1 mg | sc-204381 | 1 mg | $200.00 |