Molecular structure of VEGFR Tyrosine Kinase Inhibitor II, CAS Number: 269390-69-4
VEGFR Tyrosine Kinase Inhibitor II (CAS 269390-69-4)
See product citations (1)
Alternate Names:
N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II
Application:
VEGFR Tyrosine Kinase Inhibitor II is an agent that potently inhibits kinase activities of Flk-1 (KDR), Flt-1 and c-Kit
CAS Number:
269390-69-4
Purity:
≥95%
Molecular Weight:
337.8
Molecular Formula:
C19H16ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
VEGFR Tyrosine Kinase Inhibitor II is a pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. The compound may act to potently inhibit the kinase activities of Flk-1 (KDR), Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM). VEGFR Tyrosine Kinase Inhibitor II is inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50 > 10 muM).
VEGFR Tyrosine Kinase Inhibitor II (CAS 269390-69-4) References
- Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. | Tang, JY., et al. 2010. PLoS One. 5: e11822. PMID: 20686605
- Prostaglandin E₂ regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells. | Fujino, H., et al. 2011. Biochem Pharmacol. 81: 379-87. PMID: 21070749
- Polysaccharides from astragali radix restore chemical-induced blood vessel loss in zebrafish. | Hu, G., et al. 2012. Vasc Cell. 4: 2. PMID: 22357377
- VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. | Li, S., et al. 2014. Toxicol Appl Pharmacol. 280: 408-20. PMID: 25234792
- Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. | Li, S., et al. 2015. Biochim Biophys Acta. 1850: 373-84. PMID: 25450186
- Lanthanide Hydroxide Nanoparticles Induce Angiogenesis via ROS-Sensitive Signaling. | Zhao, H., et al. 2016. Small. 12: 4404-11. PMID: 27383397
- Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish. | Chen, Y., et al. 2018. J Ethnopharmacol. 219: 152-160. PMID: 29126989
- Pro-angiogenic effects of Ilexsaponin A1 on human umbilical vein endothelial cells in vitro and zebrafish in vivo. | Li, J., et al. 2017. Phytomedicine. 36: 229-237. PMID: 29157819
- Pro-angiogenic activity of isoliquiritin on HUVECs in vitro and zebrafish in vivo through Raf/MEK signaling pathway. | Zhang, XH., et al. 2019. Life Sci. 223: 128-136. PMID: 30876941
- Pro-angiogenesis effect and transcriptome profile of Shuxinyin formula in zebrafish. | Zhou, ZY., et al. 2019. Phytomedicine. 65: 153083. PMID: 31600690
- Buxue Yimu Pills improve angiogenesis and blood flow in experimental zebrafish and rat models. | Zhang, LL., et al. 2022. J Ethnopharmacol. 289: 115002. PMID: 35065249
- Structural determination and pro-angiogenic effect of polysaccharide from the pollen of Typha angustifolia L. | Gao, M., et al. 2022. Int J Biol Macromol. 222: 2028-2040. PMID: 36209909
- Xinkeshu tablets promote angiogenesis in zebrafish embryos and human umbilical vein endothelial cells through multiple signaling pathways. | Liu, Q., et al. 2023. J Ethnopharmacol. 116636. PMID: 37182673
Inhibitor of:
c-Kit, Flk-1, Flt, Flt-1, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VEGFR Tyrosine Kinase Inhibitor II, 5 mg | sc-204378 | 5 mg | $208.00 |