vaspin Antibody (1C4): sc-81666

vaspin Antibody (1C4) is a mouse monoclonal IgG1 antibody that detects vaspin protein of human origin by western blotting (WB) and immunoprecipitation (IP). anti-vaspin antibody (1C4) is available as a non-conjugated format. Vaspin, also known as SERPINA12, is a 414 amino acid secreted protein that plays a crucial role in regulating insulin activity within adipose tissue, particularly in the presence of specific proteases. This regulation influences metabolic processes and can impact the development of obesity and type 2 diabetes, conditions increasingly prevalent in modern society. Vaspin is primarily expressed in visceral adipose tissue, where vaspin acts as a serine proteinase inhibitor, modulating the activity of various proteases that can affect insulin signaling pathways. The gene encoding vaspin is located on human chromosome 14, which contains over 700 genes and represents nearly 3.5% of the human genome. Understanding vaspin function and interactions within metabolic pathways is essential for developing therapeutic strategies aimed at combating metabolic disorders.

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vaspin Antibody (1C4) References:

1. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.  |  Namciu, SJ., et al. 2004. Mamm Genome. 15: 162-78. PMID: 15014966
2. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity.  |  Hida, K., et al. 2005. Proc Natl Acad Sci U S A. 102: 10610-5. PMID: 16030142
3. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes.  |  Klöting, N., et al. 2006. Biochem Biophys Res Commun. 339: 430-6. PMID: 16298335
4. Serum vaspin concentrations in human obesity and type 2 diabetes.  |  Youn, BS., et al. 2008. Diabetes. 57: 372-7. PMID: 17991760
5. Vaspin: a novel serpin with insulin-sensitizing effects.  |  Wada, J. 2008. Expert Opin Investig Drugs. 17: 327-33. PMID: 18321232
6. Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.  |  Tan, BK., et al. 2008. Diabetes. 57: 1501-7. PMID: 18375437
7. Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies.  |  Kempf, K., et al. 2010. Exp Clin Endocrinol Diabetes. 118: 184-9. PMID: 18726871
8. [Vaspin and insulin resistance].  |  Wada, J. 2008. Rinsho Byori. 56: 705-11. PMID: 18800627
9. Serum vaspin levels in type 2 diabetic women in relation to microvascular complications.  |  Gulcelik, NE., et al. 2009. Eur J Endocrinol. 160: 65-70. PMID: 18952766

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-vaspin Antibody (1C4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-vaspin Antibody (1C4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

vaspin Antibody (1C4) Specifications

Alternate Product Name: vaspin

Product Clone Name: 1C4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 21-414

Epitope Target: vaspin

Epitope Species: human

Product Reactivity/Detection: vaspin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for vaspin Antibody (1C4): N/A