Vasicine (CAS 6159-55-3)
Alternate Names:
(−)-Peganine
CAS Number:
6159-55-3
Molecular Weight:
188.2
Molecular Formula:
C11H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vasicine is a natural alkaloid that is primarily used in research to study its biological activity in various in vitro systems. In plant biology, it is of interest for its role in plant defense mechanisms and secondary metabolite pathways. Biochemists investigate vasicine′s interactions with enzymes and receptors to elucidate its mechanism of action at the molecular level. Additionally, it is used in the study of alkaloid biosynthesis pathways, contributing to the understanding of how these compounds are produced in nature. Vasicine is also a subject in chemical ecology research, where it is examined for its effects on plant-insect interactions and as a potential bioactive lead compound for the development of new molecules.
Vasicine (CAS 6159-55-3) References
- Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis. | Avula, B., et al. 2008. Pharmazie. 63: 20-2. PMID: 18271297
- High-performance thin-layer chromatography densitometric method for the quantification of harmine, harmaline, vasicine, and vasicinone in Peganum harmala. | Pulpati, H., et al. 2008. J AOAC Int. 91: 1179-85. PMID: 18980138
- Validation of Different Methods of Preparation of Adhatoda vasica Leaf Juice by Quantification of Total Alkaloids and Vasicine. | Soni, S., et al. 2008. Indian J Pharm Sci. 70: 36-42. PMID: 20390078
- Formulation and pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine. | Vyas, T., et al. 2011. Fitoterapia. 82: 446-53. PMID: 21187127
- Metal-free transfer hydrogenation of nitroarenes in water with vasicine: revelation of organocatalytic facet of an abundant alkaloid. | Sharma, S., et al. 2014. J Org Chem. 79: 9433-9. PMID: 25215900
- In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor. | Liu, W., et al. 2015. PLoS One. 10: e0122366. PMID: 25849329
- Correction: In Vitro and In Vivo Metabolism and Inhibitory Activities of Vasicine, a Potent Acetylcholinesterase and Butyrylcholinesterase Inhibitor. | Liu, W., et al. 2015. PLoS One. 10: e0129759. PMID: 26046918
- Interaction of vasicine with calf thymus DNA: Molecular docking, spectroscopic and differential scanning calorimetric insights. | R S, SM., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 180: 217-223. PMID: 28315618
- Simultaneous determination of vasicine and vasicinone by High-performance liquid chromatography in roots of eight Sida species. | Subramanya, MD., et al. 2016. Ayu. 37: 135-139. PMID: 29200752
- Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo. | Zhu, Y., et al. 2018. Eur J Pharm Sci. 123: 459-474. PMID: 30077712
- Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway. | Jiang, T., et al. 2019. Drug Des Devel Ther. 13: 3773-3784. PMID: 31802850
- Cu(II)/Vasicine Promoted Intramolecular C-O Formation: Synthesis of Benzoxazoles in EtOH. | Li, M., et al. 2021. Curr Org Synth. 18: 310-315. PMID: 33167843
- Vasicine alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis and passive cutaneous anaphylaxis in BALB/c mice. | Zhang, Y., et al. 2022. Clin Immunol. 244: 109102. PMID: 36049600
- Discovery of multi-target directed 3-OH pyrrolidine derivatives through a semisynthetic approach from alkaloid vasicine for the treatment of Alzheimer's disease. | Bhanukiran, K., et al. 2023. Eur J Med Chem. 249: 115145. PMID: 36706620
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vasicine, 10 mg | sc-491945 | 10 mg | $342.00 |