Molecular structure of Vardenafil, Hydrochloride Salt, CAS Number: 224785-91-5
Vardenafil, Hydrochloride Salt (CAS 224785-91-5)
Alternate Names:
Vardenafil, Hydrochloride Salt is known as a phosphodiesterase type 5 (PDE 5) enzyme inhibitor.
Application:
Vardenafil, Hydrochloride Salt is a cGMP specific phosphodiesterase type 5 (PDE 5) enzyme inhibitor.
CAS Number:
224785-91-5
Molecular Weight:
525.06
Molecular Formula:
C23H32N6O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Vardenafil, Hydrochloride Salt inhibits the cGMP specific phosphodiesterase type 5 (PDE 5), which increases the amount of cGMP. The metabolism of Vardenafil, Hydrochloride Salt is primarily by CYP3A4. Vardenafil, Hydrochloride Salt is also known as 1-((3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine Hydrochloride, and 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride.
Vardenafil, Hydrochloride Salt (CAS 224785-91-5) References
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- A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. | Bischoff, E. and Schneider, K. 2001. Int J Impot Res. 13: 230-5. PMID: 11494080
- Therapeutic options for patients returning to sexual activity. | Nusbaum, MR. 2004. J Am Osteopath Assoc. 104: S2-5. PMID: 15083992
- The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues. | Aziz, MT., et al. 2008. J Sex Med. 5: 1636-45. PMID: 18208506
- Development of a method for the determination of vardenafil in human plasma by high performance liquid chromatography with UV detection. | Carlucci, G., et al. 2009. Biomed Chromatogr. 23: 759-63. PMID: 19296519
- A validated rapid stability-indicating method for the determination of related substances in solifenacin succinate by ultra-fast liquid chromatography. | Krishna, SR., et al. 2010. J Chromatogr Sci. 48: 807-10. PMID: 21044410
- Validated UPLC-MS/MS assay for the determination of synthetic phosphodiesterase type-5 inhibitors in postmortem blood samples. | Proença, P., et al. 2013. J Forensic Leg Med. 20: 655-8. PMID: 23910856
- Prednisone and vardenafil hydrochloride for refractory levamisole-induced vasculitis. | Mandrell, J. and Kranc, CL. 2016. Cutis. 98: E15-9. PMID: 27622263
- Polyamidoamine (PAMAM) dendrimers as potential release modulators and oral bioavailability enhancers of vardenafil hydrochloride. | Tawfik, MA., et al. 2019. Pharm Dev Technol. 24: 293-302. PMID: 29723110
- Lipomers (Lipid-polymer Hybrid Particles) of Vardenafil Hydrochloride: a Promising Dual Platform for Modifying the Drug Release Rate and Enhancing Its Oral Bioavailability. | Tawfik, MA., et al. 2018. AAPS PharmSciTech. 19: 3650-3660. PMID: 30291543
- Ocular side effects of Levitra® (vardenafil) - results of a double-blind crossover study in healthy male subjects. | Roessler, G., et al. 2019. Drug Des Devel Ther. 13: 37-43. PMID: 30587926
- Ethosome-Derived Invasomes as a Potential Transdermal Delivery System for Vardenafil Hydrochloride: Development, Optimization and Application of Physiologically Based Pharmacokinetic Modeling in Adults and Geriatrics. | Ammar, HO., et al. 2020. Int J Nanomedicine. 15: 5671-5685. PMID: 32821096
- Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability. | Wiergowska, G., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34064796
- Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride. | Elama, HS., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 266: 120420. PMID: 34619505
Inhibitor of:
Enzyme, and PDE5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vardenafil, Hydrochloride Salt, 25 mg | sc-394434 | 25 mg | $87.00 | |||
Vardenafil, Hydrochloride Salt, 100 mg | sc-394434A | 100 mg | $202.00 | |||
Vardenafil, Hydrochloride Salt, 1 g | sc-394434B | 1 g | $393.00 |