Molecular structure of Vapiprost hydrochloride, CAS Number: 87248-13-3
Vapiprost hydrochloride (CAS 87248-13-3)
See product citations (1)
Alternate Names:
GR 32191B
Application:
Vapiprost hydrochloride is a selective TP prostanoid receptor antagonist
CAS Number:
87248-13-3
Purity:
≥98%
Molecular Weight:
514.10
Molecular Formula:
C30H39NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vapiprost hydrochloride is a thromboxane A2 receptor antagonist. Vapiprost inhibits the aggregation and ATP release stimulated with U-46619, collagen, or arachidonic acid (AA) at an IC50 of less than 2.1×10^-8 M. Specifically, it has inhibited U-46619-induced contraction of guinea pig trachea with IC50 =1.8 nM.
Vapiprost hydrochloride (CAS 87248-13-3) References
- Cytochrome P-450 arachidonate metabolite inhibition improves renal function in Lyon hypertensive rats. | Messer-Létienne, I., et al. 1999. Am J Hypertens. 12: 398-404. PMID: 10232500
- 20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats. | Messer-Létienne, I., et al. 1999. Eur J Pharmacol. 378: 291-7. PMID: 10493105
- Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. | Matz, RL., et al. 2000. Br J Pharmacol. 131: 303-11. PMID: 10991924
- Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. | Alvarez De Sotomayor, M., et al. 2000. Br J Pharmacol. 131: 1179-87. PMID: 11082126
- Maturation reveals a decrease in endothelium-dependent contraction induced by depolarization in the aorta of spontaneously hypertensive rats. | Matz, RL., et al. 2001. Life Sci. 69: 1791-804. PMID: 11665841
- Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins. | Walch, L., et al. 2001. Br J Pharmacol. 134: 1671-8. PMID: 11739243
- Hydrogen peroxide contracts human airways in vitro: role of epithelium. | Rabe, KF., et al. 1995. Am J Physiol. 269: L332-8. PMID: 7573466
- Myocardial ischaemia induces platelet activation with adverse electrophysiological and arrhythmogenic effects. | Flores, NA., et al. 1994. Cardiovasc Res. 28: 1662-71. PMID: 7842460
- Prostaglandin H2-thromboxane A2 and renal functions in the Lyon hypertensive rat. | Liu, KL., et al. 1994. Am J Physiol. 266: R1530-6. PMID: 8203630
- Eicosanoid-dependence of responses of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys. | Zhang, BL. and Sassard, J. 1993. Br J Pharmacol. 110: 235-8. PMID: 8220883
- Thromboxane A2 analogue, U-46619, potentiates calcium-activated force in human umbilical artery. | Crichton, CA., et al. 1993. Am J Physiol. 264: H1878-83. PMID: 8322917
- The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets. | Horie, S., et al. 1997. Biol Pharm Bull. 20: 625-31. PMID: 9212979
- Effects of prostaglandin E2, F2alpha, and latanoprost acid on isolated ocular blood vessels in vitro. | Astin, M. 1998. J Ocul Pharmacol Ther. 14: 119-28. PMID: 9572537
- Pharmacological characterization of thromboxane and prostanoid receptors in human isolated urinary bladder. | Palea, S., et al. 1998. Br J Pharmacol. 124: 865-72. PMID: 9692770
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vapiprost hydrochloride, 1 mg | sc-215104 | 1 mg | $245.00 | |||
Vapiprost hydrochloride, 5 mg | sc-215104A | 5 mg | $827.00 |