Date published: 2026-4-30

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Vanillic acid (CAS 121-34-6)

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Alternate Names:
4-Hydroxy-3-methoxybenzoic acid; Acide vanillique; Vanillate
Application:
Vanillic acid is a flavoring agent
CAS Number:
121-34-6
Purity:
≥97%
Molecular Weight:
168.15
Molecular Formula:
C8H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Vanillic acid, a naturally occurring organic compound, is present in various plants like vanilla beans and cloves. The scientific research applications of vanillic acid encompass both in vivo and in vitro studies. In vivo investigations have focused on its anti-inflammatory and antioxidant. In vitro, vanillic acid has been employed as a model compound to examine the impact of various oxidizing agents on the oxidation of aromatic compounds.


Vanillic acid (CAS 121-34-6) References

  1. Vanillic acid and syringic acid: Exceptionally robust aromatic moieties for inhibiting in vitro self-assembly of type I collagen.  |  Rasheeda, K., et al. 2018. Int J Biol Macromol. 113: 952-960. PMID: 29522822
  2. Vanillic acid mitigates the ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation.  |  Bai, F., et al. 2019. Biosci Biotechnol Biochem. 83: 531-537. PMID: 30422751
  3. Vanillic Acid Alleviates Acute Myocardial Hypoxia/Reoxygenation Injury by Inhibiting Oxidative Stress.  |  Yao, X., et al. 2020. Oxid Med Cell Longev. 2020: 8348035. PMID: 32377308
  4. Vanillic acid as phospholipase A2 and proteases inhibitor: In vitro and computational analyses.  |  S Cesar, PH., et al. 2021. Biotechnol Appl Biochem. 68: 486-496. PMID: 32420666
  5. Vanillic acid-Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity.  |  Oke, IM., et al. 2021. J Pharm Pharmacol. 73: 1703-1714. PMID: 34109975
  6. Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues.  |  Shekari, S., et al. 2021. Curr Pharm Des. 27: 4686-4692. PMID: 34218773
  7. Vanillic acid combats Vibrio alginolyticus by cell membrane damage and biofilm reduction.  |  Liu, H., et al. 2021. J Fish Dis. 44: 1799-1809. PMID: 34310732
  8. Vanillic acid and methoxyhydroquinone production from guaiacyl units and related aromatic compounds using Aspergillus niger cell factories.  |  Lubbers, RJM., et al. 2021. Microb Cell Fact. 20: 151. PMID: 34344380
  9. Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF-κB, TNF-α and COX-2 proteins in rats.  |  Singh, B., et al. 2022. Phytother Res. 36: 1338-1352. PMID: 35088468
  10. Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk.  |  El-Hefnawy, MA., et al. 2022. J Integr Neurosci. 21: 15. PMID: 35164451
  11. Vanillic acid induces mitochondrial biogenesis in SH-SY5Y cells.  |  Ay, M. 2022. Mol Biol Rep. 49: 4443-4449. PMID: 35249168
  12. Regulatory Mechanisms of Vanillic Acid in Cardiovascular Diseases: A Review.  |  Lashgari, NA., et al. 2023. Curr Med Chem. 30: 2562-2576. PMID: 36045525
  13. Biosynthesis of vanillic acid by Ochrobactrum anthropi and its applications.  |  Girawale, SD., et al. 2022. Bioorg Med Chem. 72: 117000. PMID: 36095944
  14. Conformers of Vanillic Acid and Its Monohydrate: A Rotational Spectroscopic and Theoretical Study.  |  Al-Jabiri, MH., et al. 2022. J Phys Chem A. 126: 6686-6694. PMID: 36112415
  15. Cardioprotective potential of vanillic acid.  |  Yalameha, B., et al. 2023. Clin Exp Pharmacol Physiol. 50: 193-204. PMID: 36370144

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Vanillic acid, 25 g

sc-251422
25 g
$45.00

Vanillic acid, 50 g

sc-251422A
50 g
$90.00