Vangl2 Antibody (C-8): sc-515154
- Vangl2 Antibody (C-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 268-322 mapping within a cytoplasmic domain of Vangl2 of human origin
- recommended for detection of Vangl2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Vangl2 Antibody (C-8) for WB applications. These reagents are now offered in bundles with Vangl2 Antibody (C-8) (see ordering information below).
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Vangl2 Antibody (C-8) is a mouse monoclonal IgG2a antibody that detects Vangl2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Vangl2, also known as Strabismus1 (STB1), is a crucial component of the Vang family of proteins, which are integral membrane proteins that play a significant role in establishing planar cell polarity (PCP) during embryonic development. Vangl2 is primarily localized to the cell membrane, where anti-Vangl2 antibody (C-8) can detect participation in the regulation of convergent extension movements, a process essential for proper tissue morphogenesis. Proper localization and function of Vangl2 are vital for the development of various tissues and organs, and dysregulation has been implicated in several cancers, including gastric and pancreatic cancer. Notably, Vangl2 is down-regulated in various cancer cell lines and primary tumors, highlighting potential as a biomarker for cancer progression and a target for therapeutic intervention. Vangl2 (C-8) antibody provides a reliable tool for researchers investigating developmental biology and cancer research.
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Vangl2 Antibody (C-8) References:
- Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. | Brunt, L., et al. 2021. Nat Commun. 12: 2058. PMID: 33824332
- Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells. | Gong, Y., et al. 2021. Dev Cell. 56: 2103-2120.e9. PMID: 34214490
- Vangl2 Promotes Hematopoietic Stem Cell Expansion. | Bouali, S., et al. 2022. Front Cell Dev Biol. 10: 760248. PMID: 35399538
- VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation. | Hu, Z., et al. 2023. Sci Adv. 9: eadg2339. PMID: 37352355
- PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2. | Montserrat-Gomez, M., et al. 2024. Biochim Biophys Acta Proteins Proteom. 1872: 140989. PMID: 38142947
- Nuclear VANGL2 Inhibits Lactogenic Differentiation. | Rubio, S., et al. 2024. Cells. 13: PMID: 38334614
- A vertebrate Vangl2 translational variant required for planar cell polarity. | Walton, A., et al. 2024. J Biol Chem. 300: 106792. PMID: 38403249
- Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations. | Feng, X., et al. 2024. Proc Natl Acad Sci U S A. 121: e2310283121. PMID: 38669183
- Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2. | Ying, J., et al. 2024. Proc Natl Acad Sci U S A. 121: e2400569121. PMID: 38985771
- Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. | Lu, J., et al. 2024. Elife. 12: PMID: 39269442
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vangl2 Antibody (C-8) | sc-515154 | 200 µg/ml | $322.00 | |||
Vangl2 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-541033 | 200 µg Ab; 10 µg BP | $361.00 | |||
Vangl2 Antibody (C-8): m-IgG2a BP-HRP Bundle | sc-547002 | 200 µg Ab; 10 µg BP | $361.00 |