VAMP-1/2 Antibody (4H302): sc-58310
- VAMP-1/2 Antibody (4H302) is a mouse monoclonal IgM provided at 200 µg/ml
- raised against synaptic vesicle containing fractions immunoprecipitated from human brain homogenates
- recommended for detection of VAMP-1 and VAMP-2 of mouse, rat, human, bovine, porcine and Xenopus origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for VAMP-1/2 Antibody (4H302). This work is in progress.
VAMP-1/2 Antibody (4H302) is a mouse monoclonal IgM antibody that detects VAMP-1/2 in mouse, rat, human, bovine, and porcine samples through western blotting (WB) and immunoprecipitation (IP) applications. VAMP-1 and VAMP-2, also known as vesicle-associated membrane proteins, play a crucial role in the process of exocytosis, which is essential for neurotransmitter release and various cellular signaling pathways. These proteins are primarily located on the membranes of synaptic vesicles and are vital for the fusion of these vesicles with the presynaptic membrane, facilitating the release of neurotransmitters into the synaptic cleft. The interaction of VAMPs with syntaxins and SNAPs is critical for the formation of the SNARE complex, which drives membrane fusion. Disruption of this process can lead to significant neurological disorders, highlighting the importance of VAMP-1 and VAMP-2 in maintaining proper synaptic function. Anti-VAMP-1/2 antibody (4H302) serves as an invaluable tool for researchers studying the mechanisms of exocytosis and its implications in various physiological and pathological conditions.
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VAMP-1/2 Antibody (4H302) References:
- Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins. | Kim, PK., et al. 1999. J Biol Chem. 274: 36876-82. PMID: 10601239
- Morphological and molecular heterogeneity in release sites of single neurons. | Morgenthaler, FD., et al. 2003. Eur J Neurosci. 17: 1365-74. PMID: 12713639
- Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles. | Pennuto, M., et al. 2003. Mol Biol Cell. 14: 4909-19. PMID: 14528015
- Differential expression of synaptic proteins after chronic restraint stress in rat prefrontal cortex and hippocampus. | Müller, HK., et al. 2011. Brain Res. 1385: 26-37. PMID: 21354112
- Specificity of botulinum protease for human VAMP family proteins. | Yamamoto, H., et al. 2012. Microbiol Immunol. 56: 245-53. PMID: 22289120
- HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release. | Varodayan, FP. and Harrison, NL. 2013. Front Integr Neurosci. 7: 89. PMID: 24376402
- Downregulation of splicing regulator RBFOX1 compromises visual depth perception. | Gu, L., et al. 2018. PLoS One. 13: e0200417. PMID: 30001398
- The distribution of neuromuscular junctions depends on muscle pennation, when botulinum neurotoxin receptors and SNAREs expression are uniform in the rat. | Carré, D., et al. 2022. Toxicon. 212: 34-41. PMID: 35413334
- Distribution of proteins for synaptic release in nerve endings associated with the trachealis muscle of rats. | Moriai, H., et al. 2023. Auton Neurosci. 244: 103042. PMID: 36370593
- Expression of VAMP-2-like protein in kidney collecting duct intracellular vesicles. Colocalization with Aquaporin-2 water channels. | Nielsen, S., et al. 1995. J Clin Invest. 96: 1834-44. PMID: 7560075
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VAMP-1/2 Antibody (4H302) | sc-58310 | 200 µg/ml | $316.00 |