Valtrate (CAS 18296-44-1)
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Valtrate is a naturally occurring iridoid derivative that has piqued the interest of researchers in various fields of natural product chemistry and plant sciences. This compound′s intricate structure is a subject of study for its role in plant defense mechanisms, offering insights into the evolutionary biology of the species that produce it. In synthetic organic chemistry, valtrate presents a challenging target for total synthesis, prompting investigations into new synthetic routes and methodologies that could be applied to structurally complex iridoids. Its robustness against degradation is also being studied for potential applications in the preservation of biological samples. Additionally, valtrate′s unique functional groups make it a valuable probe in the study of enzyme-substrate interactions, particularly within the context of elucidating the specificity and mechanism of terpenoid biosynthesis enzymes.
Valtrate (CAS 18296-44-1) References
- Influence of valtrate/isovaltrate on the hematopoiesis and metabolic liver activity in mice in vivo. | Braun, R., et al. 1984. Planta Med. 50: 1-4. PMID: 17340233
- Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1). | Xu, YM., et al. 2007. J Nat Prod. 70: 2045-8. PMID: 18052324
- Bioisostere of valtrate, anti-HIV principle by inhibition for nuclear export of Rev. | Tamura, S., et al. 2010. Bioorg Med Chem Lett. 20: 2159-62. PMID: 20207540
- Controlling protein transport by small molecules. | Gademann, K. 2011. Curr Drug Targets. 12: 1574-80. PMID: 21561424
- In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases. | Bettero, GM., et al. 2011. Planta Med. 77: 1702-6. PMID: 21567360
- The anxiolytic effects of valtrate in rats involves changes of corticosterone levels. | Shi, SN., et al. 2014. Evid Based Complement Alternat Med. 2014: 325948. PMID: 24782906
- Nucleo-cytoplasmic transport as a therapeutic target of cancer. | Gravina, GL., et al. 2014. J Hematol Oncol. 7: 85. PMID: 25476752
- Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study. | Sun, L., et al. 2015. J Chromatogr Sci. 53: 1597-602. PMID: 26006134
- Valtrate from Valeriana jatamansi Jones induces apoptosis and inhibits migration of human breast cancer cells in vitro. | Tian, S., et al. 2020. Nat Prod Res. 34: 2660-2663. PMID: 30638055
- Valtrate as a novel therapeutic agent exhibits potent anti-pancreatic cancer activity by inhibiting Stat3 signaling. | Chen, L., et al. 2021. Phytomedicine. 85: 153537. PMID: 33744595
- Identification of Nrf2 Activators from the Roots of Valeriana officinalis. | Afzal, S., et al. 2023. Planta Med. 89: 30-45. PMID: 35764305
- Valtrate antagonizes malignant phenotypes of lung cancer cells by reducing SLC7A11. | Xu, W. and Yu, H. 2022. Hum Exp Toxicol. 41: 9603271221124096. PMID: 36048842
- Secondary metabolites from the underground parts of Valeriana sisymbriifolia Vahl. and their in vitro cytotoxic activities. | Erdoğan, M., et al. 2023. Phytochemistry. 208: 113590. PMID: 36696936
- Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway. | Liu, X., et al. 2023. J Transl Med. 21: 147. PMID: 36829235
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Valtrate, 50 mg | sc-473975 | 50 mg | $592.00 | |||
Valtrate, 500 mg | sc-473975A | 500 mg | $4300.00 |