Date published: 2026-7-8

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Valproic Acid-d6 (CAS 87745-18-4)

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Alternate Names:
2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid; 2-Propylvaleric Acid-d6; 4-Heptanecarboxylic Acid-d6
Application:
Valproic Acid-d6 is a deuterium-labelled form of Valproic Acid
CAS Number:
87745-18-4
Purity:
≥98%
Molecular Weight:
150.25
Molecular Formula:
C8H10D6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Valproic Acid-d6 is a deuterium-labelled form of Valproic Acid. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of HDACs (histone deacetylases) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase. Metabolites of Valproic Acid are also available as: Valproic Acid (sc-213144) Valproic Acid, Sodium Salt (sc-202378) 3-Hydroxy Valproic Acid (sc-209599) 3-Keto Valproic Acid Sodium Salt (sc-216476) 4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870) rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266) Valproic Acid beta-D-Glucuronide Allyl Ester (sc-220360) Valproic Acid beta-D-Glucuronide (sc-213145) Labelled forms of Valproic Acid are available as: Valproic Acid-d6 beta-D-Glucuronide (sc-220361) rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)


Valproic Acid-d6 (CAS 87745-18-4) References

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  2. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.  |  Phiel, CJ., et al. 2001. J Biol Chem. 276: 36734-41. PMID: 11473107
  3. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.  |  Göttlicher, M., et al. 2001. EMBO J. 20: 6969-78. PMID: 11742974
  4. Valproic acid-associated vanishing bile duct syndrome.  |  Gökçe, S., et al. 2010. J Child Neurol. 25: 909-11. PMID: 20388938
  5. Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care.  |  Ikeda, K., et al. 2014. Biomed Chromatogr. 28: 1756-62. PMID: 24889681
  6. Derivatization oriented strategy for enhanced detection of valproic acid and its metabolites in human plasma and detection of valproic acid induced reactive oxygen species associated protein modifications by mass spectrometry.  |  Wu, CY. and Lu, CY. 2014. J Chromatogr A. 1374: 14-22. PMID: 25444248
  7. Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition.  |  Rosa, M., et al. 2016. Xenobiotica. 46: 1076-1084. PMID: 26936324
  8. Analysis of Valproic Acid, Salicylic Acid and Ibuprofen in Whole Blood by GC-MS.  |  Stephenson, JB., et al. 2016. J Anal Toxicol. 40: 649-652. PMID: 27562965
  9. Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury.  |  Wakam, GK., et al. 2021. J Trauma Acute Care Surg. 90: 346-352. PMID: 33230090
  10. Therapeutic drug monitoring of valproic acid using a dried plasma spot sampling device.  |  Li, Y., et al. 2021. J Mass Spectrom. 56: e4603. PMID: 33729629
  11. Valproic acid determination by liquid chromatography coupled to mass spectrometry (LC-MS/MS) in whole blood for forensic purposes.  |  Pascali, JP., et al. 2023. Drug Test Anal. 15: 128-133. PMID: 36028251
  12. Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.  |  Yang, X., et al. 2023. Biomed Chromatogr. 37: e5572. PMID: 36520520
  13. Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate.  |  Della Paschoa, OE., et al. 1998. Br J Pharmacol. 125: 1610-6. PMID: 9884091

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Valproic Acid-d6, 5 mg

sc-213146
5 mg
$426.00