Molecular structure of Valnemulin hydrochloride, CAS Number: 133868-46-9
Valnemulin hydrochloride (CAS 133868-46-9)
Application:
Valnemulin hydrochloride is an antibiotic for gastrointestinal disorders, which works by being a protein synthesis inhibitor
CAS Number:
133868-46-9
Molecular Weight:
601.28
Molecular Formula:
C31H52N2O5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Valnemulin hydrochloride (Valnemulin HCl) is a synthetic macrolide. In research applications, Valnemulin hydrochloride is employed to explore the action mechanisms of macrolide antibiotics and assess the effectiveness of antimicrobial agents. These investigations often take place in vitro, meaning they are performed within controlled environments such as cell cultures or petri dishes, providing insights into the antibacterial capabilities of the compound. As a macrolide antibiotic, Valnemulin hydrochloride operates by blocking protein synthesis in bacteria, specifically by attaching to the 50S ribosomal subunit and hindering the formation of peptide bonds that are essential for bacterial growth and replication.
Valnemulin hydrochloride (CAS 133868-46-9) References
- The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome. | Poulsen, SM., et al. 2001. Mol Microbiol. 41: 1091-9. PMID: 11555289
- Pharmacokinetics and bioavailability of valnemulin in broiler chickens. | Wang, R., et al. 2011. J Vet Pharmacol Ther. 34: 247-51. PMID: 21492189
- Pharmacokinetics and bioavailability of valnemulin in Muscovy ducks (Cairina moschata). | Sun, J., et al. 2012. Br Poult Sci. 53: 374-8. PMID: 22978594
- Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics. | Xiao, X., et al. 2014. J Vet Pharmacol Ther. 37: 99-102. PMID: 23782411
- Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration. | Zhao, DH., et al. 2014. Vet J. 201: 109-15. PMID: 24906499
- Preparation of valnemulin hydrogen fumarate and its enhanced stability compared with valnemulin hydrochloride. | Zhu, X., et al. 2016. Pharm Dev Technol. 21: 338-45. PMID: 25597619
- Efficacy and tolerability of early administration of valnemulin hydrochloride premix on epizootic rabbit enteropathy. | Dip, R., et al. 2015. Vet J. 204: 309-14. PMID: 25956341
- Synthesis, characterization and in vitro release performance of the pegylated valnemulin prodrug. | Dong, X., et al. 2018. J Vet Med Sci. 80: 173-180. PMID: 29187697
- Preparation, characterization, and in vivo evaluation of a polymorphic form of valnemulin hydrogen tartrate. | Zhu, X., et al. 2019. J Vet Sci. 20: e16. PMID: 30944538
- Preparation and Evaluation of Valnemulin Hydrochloride Taste-Masking Granules. | Liang, Y., et al. 2022. Curr Drug Deliv. 19: 337-346. PMID: 34477518
- Efficacy of In-Feed Valnemulin Hydrochloride for the Treatment and Control of Ileitis in Weaning and Growing Pigs | E. D. Tzika, V. G. Papatsiros, S. C. Kyriakis, C. Alexopoulos, A. G. Lymberopoulos & C. S. Kyriakis. 2009. Journal of Applied Animal Research. 35: 181-184.
- Thermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride | Jinbo Ouyang, Jingkang Wang, Yongli Wang, Qiuxiang Yin & Hongxun Hao. 2015. Frontiers of Chemical Science and Engineering. 9: 94–104.
- Crystal structures and phase transformation of two novel solvates of valnemulin hydrochloride | inbo Ouyang, *ab Bing Na,ab Limin Zhou,b Saijin Xiao,b Guoxuan Xiongb and Tianxiang Jinab. 2018. CrystEngComm. 20: 563-569.
- Determination of Solubility and Nucleation Kinetics of Valnemulin Hydrochloride Solvate | Jinbo Ouyang, Bing Na, Zhirong Liu, Limin Zhou & Hongxun Hao. 2019. Journal of Solution Chemistry. 48: 413–426.
- Composite inclusion complexes containing sodium alginate composite nanogels for pH-responsive valnemulin hydrochloride release | Jinhuan Liu a #, Mujie Ju a #, Ding Guan a, Wei Song a, Samah Attia Algharib c d, Wanhe Luo a b. 2022. Journal of Molecular Structure. 1263: 133054.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Valnemulin hydrochloride, 25 mg | sc-391635 | 25 mg | $90.00 |