Molecular structure of Validamycin A, CAS Number: 37248-47-8
Validamycin A (CAS 37248-47-8)
See product citations (2)
Alternate Names:
Validamycin A is also known as Validacin.
Application:
Validamycin A is is an antibiotic fungicide that inhibits trehalase activity in plants, insects, and fungi.
CAS Number:
37248-47-8
Purity:
≥60%
Molecular Weight:
497.50
Molecular Formula:
C20H35NO13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Validamycin A is an compound produced by the soil bacterium Streptomyces hygroscopicus. It functions primarily as a potent inhibitor of trehalase, an enzyme responsible for the hydrolysis of trehalose into glucose molecules. This specific mode of action disrupts the energy supply in various plant-pathogenic fungi, thereby halting their growth and proliferation. Beyond its direct antifungal effects, Validamycin A serves as a vital tool in research, enabling scientists to explore the complex interactions between fungal pathogens and plant hosts. Its unique mechanism also provides a valuable model for studying trehalose metabolism, offering insights into the regulatory pathways that control fungal virulence and plant defense mechanisms.
Validamycin A (CAS 37248-47-8) References
- The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. | Wang, ZJ., et al. 2013. Int J Biol Macromol. 55: 15-23. PMID: 23295203
- Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster. | Zhou, TC., et al. 2014. Appl Microbiol Biotechnol. 98: 7911-22. PMID: 25060680
- Analysis of validamycin as a potential antifungal compound against Candida albicans. | Guirao-Abad, JP., et al. 2013. Int Microbiol. 16: 217-25. PMID: 25102722
- Production of validamycin A from hemicellulose hydrolysate by Streptomyces hygroscopicus 5008. | Zhou, TC. and Zhong, JJ. 2015. Bioresour Technol. 175: 160-6. PMID: 25459817
- Novel spectrophotometric approach for determination of validamycin A in fermentation of Streptomyces hygroscopicus. | Li, W., et al. 2016. J Biosci Bioeng. 122: 736-739. PMID: 27296090
- Omics for understanding synergistic action of validamycin A and Trichoderma asperellum GDFS1009 against maize sheath blight pathogen. | Wu, Q., et al. 2017. Sci Rep. 7: 40140. PMID: 28057927
- Alkaline pH shock enhanced production of validamycin A in fermentation of Streptomyces hygroscopicus. | Jiang, J., et al. 2018. Bioresour Technol. 249: 234-240. PMID: 29045927
- Validamycin A Delays Development and Prevents Flight in Aedes aegypti (Diptera: Culicidae). | Marten, AD., et al. 2020. J Med Entomol. 57: 1096-1103. PMID: 31982917
- The Inhibitory Effect of Validamycin A on Aspergillus flavus. | Plabutong, N., et al. 2020. Int J Microbiol. 2020: 3972415. PMID: 32676114
- Validamycin A Induces Broad-Spectrum Resistance Involving Salicylic Acid and Jasmonic Acid/Ethylene Signaling Pathways. | Bian, C., et al. 2020. Mol Plant Microbe Interact. 33: 1424-1437. PMID: 32815479
- Mechanism of validamycin A inhibiting DON biosynthesis and synergizing with DMI fungicides against Fusarium graminearum. | Bian, C., et al. 2021. Mol Plant Pathol. 22: 769-785. PMID: 33934484
- Residue behavior and risk assessment of validamycin a in grape under field conditions. | Yu, J., et al. 2021. J Environ Sci Health B. 56: 587-593. PMID: 34102954
- Validamycin A Enhances the Interaction Between Neutral Trehalase and 14-3-3 Protein Bmh1 in Fusarium graminearum. | Ren, L., et al. 2022. Phytopathology. 112: 290-298. PMID: 34156266
Inhibitor of:
Trehalase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Validamycin A, 1 g | sc-281183 | 1 g | $156.00 | |||
Validamycin A, 5 g | sc-281183A | 5 g | $298.00 | |||
Validamycin A, 10 g | sc-281183B | 10 g | $544.00 | |||
Validamycin A, 25 g | sc-281183C | 25 g | $738.00 |