Molecular structure of Valganciclovir Hydrochloride, CAS Number: 175865-59-5
Valganciclovir Hydrochloride (CAS 175865-59-5)
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Alternate Names:
Valganciclovir
Application:
Valganciclovir Hydrochloride is a pro-drug of ganciclovir
CAS Number:
175865-59-5
Molecular Weight:
390.82
Molecular Formula:
C14H22N6O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Valganciclovir Hydrochloride (Val-HCl) is a precursor of ganciclovir, which is an acyclic nucleoside analogue of guanosine. This compound inhibits the replication of cytomegalovirus (CMV). Ganciclovir acts as a competitive inhibitor of the viral DNA polymerase, thereby preventing the replication of the virus. Valganciclovir Hydrochloride has also been shown to have antiviral activity against other viruses, such as herpes simplex virus and human immunodeficiency virus (HIV). In addition, Valganciclovir Hydrochloride is used to inhibit the activation of the nuclear factor-kappa B (NF-κB) pathway and the expression of pro-inflammatory cytokines, such as interleukin-6 (IL-6).
Valganciclovir Hydrochloride (CAS 175865-59-5) References
- Does valganciclovir hydrochloride (valcyte) provide effective prophylaxis against cytomegalovirus infection in liver transplant recipients? | Jain, A., et al. 2005. Transplant Proc. 37: 3182-6. PMID: 16213344
- Valganciclovir for the prevention and treatment of CMV in solid organ transplant recipients. | Asberg, A., et al. 2010. Expert Opin Pharmacother. 11: 1159-66. PMID: 20367273
- Valganciclovir: therapeutic role in pediatric solid organ transplant recipients. | Yu, MA. and Park, JM. 2013. Expert Opin Pharmacother. 14: 807-15. PMID: 23469871
- New Developments in the Management of Cytomegalovirus Infection After Transplantation. | Meesing, A. and Razonable, RR. 2018. Drugs. 78: 1085-1103. PMID: 29961185
- Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial. | Singh, N., et al. 2020. JAMA. 323: 1378-1387. PMID: 32286644
- Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions. | Razonable, RR. 2020. Curr Pharm Des. 26: 3497-3506. PMID: 32473617
- Epidemiology, risk factors, and outcomes associated with cytomegalovirus in adult kidney transplant recipients: A systematic literature review of real-world evidence. | Raval, AD., et al. 2021. Transpl Infect Dis. 23: e13483. PMID: 33012092
- Development of non-aqueous titrimetric and spectrophotometric methods for the determination of valganciclovir hydrochloride in bulk drug and tablets. | Abdulrahman, SAM., et al. 2021. Ann Pharm Fr. 79: 489-499. PMID: 33548279
- Valganciclovir therapy for a neonate with congenital cytomegalovirus pneumonitis. | Kanda, R., et al. 2021. Pediatr Int. 63: 1526-1528. PMID: 34399019
- Pharmacokinetics, Pharmacodynamics, and Therapeutic Drug Monitoring of Valganciclovir and Ganciclovir in Transplantation. | Franck, B., et al. 2022. Clin Pharmacol Ther. 112: 233-276. PMID: 34596243
- Therapeutic Drug Monitoring of Ganciclovir: Where Are We? | Märtson, AG., et al. 2022. Ther Drug Monit. 44: 138-147. PMID: 34610621
- Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results From a Phase 3 Randomized Clinical Trial. | Avery, RK., et al. 2022. Clin Infect Dis. 75: 690-701. PMID: 34864943
- Clinical characteristics and treatment outcomes of cytomegalovirus anterior uveitis and endotheliitis: A systematic review and meta-analysis. | La Distia Nora, R., et al. 2022. Surv Ophthalmol. 67: 1014-1030. PMID: 34954093
- Cytomegalovirus variation among newborns treated with valganciclovir. | Dobbins, GC., et al. 2022. Antiviral Res. 203: 105326. PMID: 35504491
- New Perspectives on Antimicrobial Agents: Maribavir. | Halpern-Cohen, V. and Blumberg, EA. 2022. Antimicrob Agents Chemother. 66: e0240521. PMID: 35916518
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Valganciclovir Hydrochloride, 10 mg | sc-213141 | 10 mg | $255.00 |