Valeric acid (CAS 109-52-4)
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Valeric acid, also known as pentanoic acid, is a versatile saturated fatty acid characterized by its five-carbon chain and acyclic structure. It exists as a colorless, odorless, and slightly acidic liquid, finding application in various industries. Valeric acid has contributed to the exploration of fatty acids′ effects on cell membrane structure and function, along with their role in modulating the immune system. Metabolically, valeric acid undergoes breakdown by the enzyme fatty acid oxidation within the body. This breakdown process cleaves the fatty acid into acetic acid and acetyl-CoA, where the latter participates in the citric acid cycle, facilitating energy production. Additionally, valeric acid can be metabolized to generate ketone bodies, which serve as an energy source for the brain and other organs.
Valeric acid (CAS 109-52-4) References
- Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity. | Park, JH., et al. 2016. Biotechnol J. 11: 487-96. PMID: 26663903
- GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples. | Hoving, LR., et al. 2018. Methods Mol Biol. 1730: 247-256. PMID: 29363078
- Valeric acid glyceride esters in feed promote broiler performance and reduce the incidence of necrotic enteritis. | Onrust, L., et al. 2018. Poult Sci. 97: 2303-2311. PMID: 29562369
- Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder. | Liu, S., et al. 2019. Sci Rep. 9: 287. PMID: 30670726
- A rapid derivatization based LC-MS/MS method for quantitation of short chain fatty acids in human plasma and urine. | Jaochico, A., et al. 2019. Bioanalysis. 11: 741-753. PMID: 30993998
- Gut commensal derived-valeric acid protects against radiation injuries. | Li, Y., et al. 2020. Gut Microbes. 11: 789-806. PMID: 31931652
- Valeric Acid, a Gut Microbiota Product, Penetrates to the Eye and Lowers Intraocular Pressure in Rats. | Skrzypecki, J., et al. 2020. Nutrients. 12: PMID: 32024034
- Valeric acid lowers arterial blood pressure in rats. | Onyszkiewicz, M., et al. 2020. Eur J Pharmacol. 877: 173086. PMID: 32234527
- Valeric Acid Suppresses Liver Cancer Development by Acting as a Novel HDAC Inhibitor. | Han, R., et al. 2020. Mol Ther Oncolytics. 19: 8-18. PMID: 33024815
- Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways. | Jayaraj, RL., et al. 2020. Int J Mol Sci. 21: PMID: 33081327
- Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice. | Lai, Z., et al. 2021. Mol Psychiatry. 26: 7167-7187. PMID: 34663905
- A Novel Targeted Delivery of Valeric Acid Using Liposomal Nanoparticles in Treatment of Lung Cell Carcinoma. | Chen, H., et al. 2022. J Biomed Nanotechnol. 18: 211-217. PMID: 35180914
- Valeric acid acts as a novel HDAC3 inhibitor against prostate cancer. | Han, R., et al. 2022. Med Oncol. 39: 213. PMID: 36175803
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Valeric acid, 5 ml | sc-216049 | 5 ml | $41.00 | |||
Valeric acid, 100 ml | sc-216049A | 100 ml | $50.00 |