Molecular structure of Vacuolin-1, CAS Number: 351986-85-1
Vacuolin-1 (CAS 351986-85-1)
See product citations (29)
Alternate Names:
Vacuolin-1 is known as a PIKfyve inhibitor.
Application:
Vacuolin-1 is a cell-permeable triazine that inhibits Ca2+-dependent fusion of lysosomes to the cell membrane inhibiting release of lysosomal content.
CAS Number:
351986-85-1
Purity:
≥95%
Molecular Weight:
577.42
Molecular Formula:
C26H24IN7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Vacuolin-1 is a lysosomal exocytosis inhibitor that prevents Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content. Vacuolin-1 alters the morphology of lysosomes, but not their cell resealing. Vacuolin-1 is cell-permeable. Vacuolin-1 does not disturb the organization of the actin or tubulin cytoskeletal networks. Vacuolin-1 also does not interfere with trafficking along the endocytic or secretory pathways.
Vacuolin-1 (CAS 351986-85-1) References
- The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. | Cerny, J., et al. 2004. EMBO Rep. 5: 883-8. PMID: 15332114
- The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. | Huynh, C. and Andrews, NW. 2005. EMBO Rep. 6: 843-7. PMID: 16113649
- Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. | Lu, Y., et al. 2014. Autophagy. 10: 1895-905. PMID: 25483964
- Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. | Sano, O., et al. 2016. FEBS Lett. 590: 1576-85. PMID: 27135648
- Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis. | Chen, C., et al. 2017. Molecules. 22: PMID: 28555021
- Vacuolin-1 potently and reversibly inhibits autophagy by activating Rab5. | . 2018. Autophagy. 14: 176-177. PMID: 29388871
- Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA delivery. | Li, T., et al. 2019. Biochem Biophys Res Commun. 510: 427-434. PMID: 30732855
- Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ. | Ye, Z., et al. 2021. Oncogene. 40: 1775-1791. PMID: 33564074
- Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation - A new tool to study autophagosome-lysosome fusion. | Tanaka, Y., et al. 2022. Biochem Biophys Res Commun. 614: 191-197. PMID: 35598430
- Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. | Hu, M., et al. 2022. Cell. 185: 2292-2308.e20. PMID: 35750034
- The Three Two-Pore Channel Subtypes from Rabbit Exhibit Distinct Sensitivity to Phosphoinositides, Voltage, and Extracytosolic pH. | Feng, X., et al. 2022. Cells. 11: PMID: 35805090
- A Structural Overview of TRPML1 and the TRPML Family. | Fine, M. and Li, X. 2022. Handb Exp Pharmacol.. PMID: 35879577
- Correction: Vacuolin‑1 enhances RA‑induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP‑76 axis subject to endosomal regulation that drives late differentiation steps. | Zhu, K., et al. 2023. Cell Biosci. 13: 22. PMID: 36737806
Inhibitor of:
CHMP4B, CHMP6, MVB12B, Rab 5A, Rab 5C, RSC1A1, RUFY1, SNX8, VPS37, and ZFYVE27.Activator of:
NEURL4, V-ATPase C1, and VMA21.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vacuolin-1, 10 mg | sc-216045 | 10 mg | $260.00 |