Molecular structure of V2R Antagonist, V2Rnh-02
V2R Antagonist, V2Rnh-02
Alternate Names:
4-Benzoyl-5-(4-fluorophenyl)-3-hydroxy-1-(4-hydroxyphenylethyl)-2,5-dihydro-2-pyrrolone
Application:
V2R Antagonist, V2Rnh-02 is a ligand-competitive vasopressin receptor antagonist with affinity for V2R
Purity:
≥98%
Molecular Weight:
417.4
Molecular Formula:
C25H20FNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
V2R Antagonist, V2Rnh-02 is a pyrrolone compound that acts as a ligand-competitive vasopressin receptor antagonist with ~70-fold greater affinity for V2R than V1aR (IC50 against arginine vasopression binding = 70 nM and 5 µM, respectively). It has shown to selectively inhibit cellular cAMP production mediated by V2R (IC50 = 60 nM), but not β2-adrengergic receptor. It is reported to exhibit great aqueous solubility (377 μM in PBS) with a pKa of 4.76.
V2R Antagonist, V2Rnh-02 References
- Small-molecule vasopressin-2 receptor antagonist identified by a g-protein coupled receptor 'pathway' screen. | Yangthara, B., et al. 2007. Mol Pharmacol. 72: 86-94. PMID: 17435162
Inhibitor of:
AVP Receptor V2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
V2R Antagonist, V2Rnh-02, 10 mg | sc-222408 | 10 mg | $260.00 |