Molecular structure of (+)-Usnic acid, CAS Number: 7562-61-0
(+)-Usnic acid (CAS 7562-61-0)
CAS Number:
7562-61-0
Purity:
≥98%
Molecular Weight:
344.32
Molecular Formula:
C18H16O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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(+)-Usnic acid is the enantiomerically pure form of usnic acid, known for displaying enhanced biological functionalities compared to its racemic mixture. It is a yellow crystalline solid, showing sparse solubility in water but dissolving with ease in organic mediums like ethanol and chloroform. It inhibits mitochondrial respiration, specifically by binding to complex I of the electron transport chain, thus stopping proton pumping, resulting in a lowered mitochondrial membrane potential and potentially causing apoptosis. (+)-Usnic acid has been used to study the mechanism of its antimicrobial activity in bacterial cells and its ability as an antibiofilm agent, especially against Group A Streptococci.
(+)-Usnic acid (CAS 7562-61-0) References
- Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo. | Wang, H., et al. 2022. Molecules. 27: PMID: 36364296
- Liposomal Formulation Improves the Bioactivity of Usnic Acid in RAW 264.7 Macrophage Cells Reducing its Toxicity. | Vasarri, M., et al. 2023. Curr Drug Deliv.. PMID: 36631924
- Divergent reactivity of usnic acid and evaluation of its derivatives for antiproliferative activity against cancer cells. | Gunawan, GA., et al. 2023. Bioorg Med Chem. 79: 117157. PMID: 36652792
- Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation. | Wong, KKV., et al. 2023. J Biomol Struct Dyn. 1-14. PMID: 36794726
- mRNA sequencing and CyTOF analysis revealed ASPP2 altered the response patterns of hepatocellular carcinoma HepG2 cells to usnic acid. | Wang, Y., et al. 2023. Naunyn Schmiedebergs Arch Pharmacol.. PMID: 36877271
- Assessing the Fate of Superparamagnetic Iron Oxide Nanoparticles Carrying Usnic Acid as Chemical Cargo on the Soil Microbial Community. | Pontes, MS., et al. 2023. ACS Nano. 17: 7417-7430. PMID: 36877273
- In silico evaluation of usnic acid derivatives to discover potential antibacterial drugs against DNA gyrase B and DNA topoisomerase IV. | Roney, M., et al. 2023. J Biomol Struct Dyn. 1-10. PMID: 36995164
- [Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo]. | Kornienko, TE., et al. 2023. Mol Biol (Mosk). 57: 220-231. PMID: 37000651
- Effects of the Dibenzofuran, Usnic Acid, on Inhibition of Ocular Biofilm Formation Due to Coagulase-Negative Staphylococci. | Kıvanç, SA., et al. 2023. Med Sci Monit. 29: e940266. PMID: 37073093
- Critical Assessment of the Anti-Inflammatory Potential of Usnic Acid and Its Derivatives-A Review. | Paździora, W., et al. 2023. Life (Basel). 13: PMID: 37109575
- Protocol for assessing the healthspan of Caenorhabditis elegans after potential anti-aging drug treatment. | Xiao, Y., et al. 2023. STAR Protoc. 4: 102285. PMID: 37148246
- Unravelling Novel Phytochemicals and Anticholinesterase Activity in Irish Cladonia portentosa. | Nagar, S., et al. 2023. Molecules. 28: PMID: 37241886
- The usnic acid derivative peziculone targets cell wall of Gram-positive bacteria revealed by high throughput CRISPRi-seq analysis. | Zhang, H., et al. 2023. Int J Antimicrob Agents. 106876. PMID: 37276892
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Usnic acid, 5 g | sc-251412 | 5 g | $50.00 |