Molecular structure of URB-754, CAS Number: 86672-58-4
URB-754 (CAS 86672-58-4)
Alternate Names:
6-Methyl-2-(p-tolylamino)-4H-benzo[d][1,3]oxazin-4-one; 6-methyl-2-((4-methylphenyl)amino)-4h-3,1-benzoxazin-4-one
Application:
URB-754 is a potent and selective inhibitor of MAG lipase which selectively raises levels of 2AG
CAS Number:
86672-58-4
Purity:
≥98%
Molecular Weight:
266.3
Molecular Formula:
C16H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
URB-754 was originally described as a potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol (2AG). Subsequent studies have shown that that URB-754 does not inhibit recombinant MAG Lipase and that the original activity was due to a contaminant, bis(methylthio)mercurane, in another commercial source. URB-754 is an inhibitor of FAAH.
URB-754 (CAS 86672-58-4) References
- Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. | Makara, JK., et al. 2005. Nat Neurosci. 8: 1139-41. PMID: 16116451
- URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. | Saario, SM., et al. 2006. Chem Biol. 13: 811-4. PMID: 16931330
- Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. | Vandevoorde, S., et al. 2007. Br J Pharmacol. 150: 186-91. PMID: 17143303
- URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products. | Uchiyama, N., et al. 2013. Forensic Sci Int. 227: 21-32. PMID: 23063179
Inhibitor of:
FAAH, and Lipid Biosynthesis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
URB-754, 10 mg | sc-200671 | 10 mg | $80.00 | |||
URB-754, 50 mg | sc-200671A | 50 mg | $240.00 |