Molecular structure of Urapidil HCl, CAS Number: 64887-14-5
Urapidil HCl (CAS 64887-14-5)
Application:
Urapidil HCl is an adrenergic α1-AR antagonist and a serotonin 5-HT1A (SR-1A) receptor agonist
CAS Number:
64887-14-5
Purity:
99%
Molecular Weight:
423.9
Molecular Formula:
C20H29N5O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Urapidil HCl functions as an α1-adrenoceptor antagonist. It acts by competitively inhibiting the binding of norepinephrine to α1-adrenoceptors, leading to vasodilation. Urapidil HCl targets the smooth muscle cells in blood vessels, causing relaxation and subsequent dilation of the vessels. By blocking the α1-adrenoceptors, Urapidil HCl prevents the vasoconstrictive effects of norepinephrine, ultimately leading to a decrease in peripheral vascular resistance. This mechanism of action results in a reduction in blood pressure, which may be useful for studying the regulation of vascular tone and blood pressure in experimental models.
Urapidil HCl (CAS 64887-14-5) References
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- Capillary electrophoresis with end-column electrochemiluminescence for ultrasensitive determination of urapidil hydrochloride in rat plasma and its application to pharmacokinetics study. | Sun, S., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 1006: 146-150. PMID: 26551206
- Excitatory effect of norepinephrine on neurons in the inferior vestibular nucleus and the underlying receptor mechanism. | Peng, SY., et al. 2016. J Neurosci Res. 94: 736-48. PMID: 27121461
- Simultaneous electrochemiluminescence determination of galanthamine, homolycorine, lycorenine, and tazettine in Lycoris radiata by capillary electrophoresis with ultrasonic-assisted extraction. | Sun, S., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1055-1056: 15-19. PMID: 28441543
- New central mediators as targets of centrally acting antihypertensive drugs. | van Zwieten, PA. 1996. Clin Exp Hypertens. 18: 291-303. PMID: 8743022
- The discriminative stimulus effects of KA 672, a putative cognitive enhancer: evidence for a 5-HT1A component. | Winter, JC., et al. 1998. Pharmacol Biochem Behav. 60: 703-7. PMID: 9678654
Inhibitor of:
AR.Activator of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Urapidil HCl, 100 mg | sc-200155 | 100 mg | $122.00 |