Date published: 2025-9-25

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Uracil (CAS 66-22-8)

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Alternate Names:
2,4(1H,3H)-Pyrimidinedione; 2,4-Dihydroxypyrimidine; 2,4-Pyrimidinediol
Application:
Uracil is a pyrimidine derivative
CAS Number:
66-22-8
Molecular Weight:
112.10
Molecular Formula:
C4H4N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Uracil is a pyrimidine derivative. Uracil, a nitrogenous base, is a component of RNA. It serves as a structural analog to thymine, a pyrimidine base in DNA. Uracil plays a vital role in numerous biochemical processes within the cell, including nucleic acid synthesis, DNA repair, and gene expression.


Uracil (CAS 66-22-8) References

  1. Vibrational Feshbach resonances in uracil and thymine.  |  Burrow, PD., et al. 2006. J Chem Phys. 124: 124310. PMID: 16599677
  2. Uracil and thymine reactivity in the gas phase: the S(N)2 reaction and implications for electron delocalization in leaving groups.  |  Zhachkina, A. and Lee, JK. 2009. J Am Chem Soc. 131: 18376-85. PMID: 19928991
  3. Covalent hybridization of CNT by thymine and uracil: a computational study.  |  Mirzaei, M., et al. 2011. J Mol Model. 17: 695-9. PMID: 20532804
  4. Nonradiative deactivation mechanisms of uracil, thymine, and 5-fluorouracil: a comparative ab initio study.  |  Yamazaki, S. and Taketsugu, T. 2012. J Phys Chem A. 116: 491-503. PMID: 22171528
  5. Shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil.  |  Kossoski, F., et al. 2014. J Chem Phys. 140: 024317. PMID: 24437887
  6. Tautomerism of uracil and related compounds: A mass spectrometry study.  |  Colasurdo, DD., et al. 2018. Eur J Mass Spectrom (Chichester). 24: 214-224. PMID: 29232994
  7. Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing.  |  Sakhtemani, R., et al. 2019. J Biol Chem. 294: 15037-15051. PMID: 31431505
  8. Insights into Cisplatin Binding to Uracil and Thiouracils from IRMPD Spectroscopy and Tandem Mass Spectrometry.  |  Corinti, D., et al. 2020. J Am Soc Mass Spectrom. 31: 946-960. PMID: 32233383
  9. Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments.  |  Pálinkás, HL., et al. 2020. Elife. 9: PMID: 32956035
  10. Probing the molecular frame of uracil and thymine with high-harmonic generation spectroscopy.  |  Luppi, E. and Coccia, E. 2021. Phys Chem Chem Phys. 23: 3729-3738. PMID: 33395454
  11. Diversity-oriented functionalization of 2-pyridones and uracils.  |  Shang, Y., et al. 2021. Nat Commun. 12: 2988. PMID: 34016986
  12. Terahertz Spectral Properties of 5-Substituted Uracils.  |  Li, K., et al. 2021. Sensors (Basel). 21: PMID: 34960387
  13. Pre-analytical considerations for the analysis of uracil and 5,6-dihydrouracil in heparin plasma.  |  Capiau, S., et al. 2022. Clin Chem Lab Med. 60: e112-e115. PMID: 35073467
  14. Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.  |  van den Wildenberg, SAH., et al. 2022. J Pharm Biomed Anal. 221: 115027. PMID: 36099723
  15. 3-Methylation alters excited state decay in photoionised uracil.  |  Segarra-Martí, J., et al. 2022. Phys Chem Chem Phys. 24: 27038-27046. PMID: 36321485

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Uracil, 5 g

sc-296682
5 g
$40.00

Uracil, 25 g

sc-296682A
25 g
$49.00