uPA/urokinase/PLAU Antibody (PGM2005): sc-59729

uPA Antibody (PGM2005) is a mouse monoclonal IgG1 antibody raised against human urinary urokinase, specifically detecting uPA of mouse, rat, and human origin by western blotting (WB) and immunofluorescence (IF) without cross-reactivity to other serine proteases. Urokinase-type plasminogen activator (uPA), also known as PLAU or urokinase, is a serine protease that plays a crucial role in the conversion of plasminogen to plasmin, thereby influencing fibrinolysis, cell migration, and tissue remodeling. uPA undergoes significant post-translational modifications, including glycosylation and proteolytic cleavage, which are essential for activation and function. These modifications regulate enzymatic activity and interactions with cell surface receptors like uPAR. The cleavage of single-chain pro-uPA into active two-chain form is a key regulatory step that controls plasminogen activation, affecting processes such as wound healing, angiogenesis, and tumor metastasis. Glycosylation of uPA affects stability and receptor binding affinity, highlighting the importance of post-translational modifications in biological activity. By providing a highly specific tool for detecting uPA, anti-uPA antibody (PGM2005) is invaluable for research into coagulation, cancer biology, and cellular processes involving extracellular matrix degradation. uPA monoclonal antibody (PGM2005) aids in elucidating the mechanisms by which uPA contributes to physiological and pathological processes, supporting the development of therapeutic strategies targeting uPA-related pathways.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-uPA/urokinase/PLAU Antibody (PGM2005) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-uPA/urokinase/PLAU Antibody (PGM2005) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

uPA/urokinase/PLAU Antibody (PGM2005) Specifications

Alternate Product Name: uPA

Product Clone Name: PGM2005

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: uPA

Epitope Species: human

Product Reactivity/Detection: uPA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for uPA/urokinase/PLAU Antibody (PGM2005): N/A

The preferred uPA/urokinase/PLAU antibody is uPA/urokinase/PLAU Antibody (H77A10): sc-59727.