Date published: 2026-3-16

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Unoprostone isopropyl ester (CAS 120373-24-2)

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Alternate Names:
9α,11α-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid, isopropyl ester; 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2α isopropyl ester
Application:
Unoprostone isopropyl ester is a free acid analog of prostoglandin F
CAS Number:
120373-24-2
Molecular Weight:
424.6
Molecular Formula:
C25H44O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Unoprostone isopropyl ester, as an activator of the prostaglandin F receptor, it acts by binding to and activating the prostaglandin F receptor, leading to the activation of downstream signaling pathways. This activation results in the modulation of ion transport and fluid movement across cellular membranes, particularly in ocular tissues. By influencing these processes, unoprostone isopropyl ester can impact the regulation of intraocular pressure. At the molecular level, it interacts with specific receptors and signaling molecules to exert its effects on ion transport and fluid dynamics within the eye. Unoprostone Isopropyl Ester′s mechanism of action involves specific interactions with cellular components that ultimately contribute to the regulation of intraocular pressure.


Unoprostone isopropyl ester (CAS 120373-24-2) References

  1. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist.  |  Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
  2. Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor.  |  Sharif, NA., et al. 2002. J Ocul Pharmacol Ther. 18: 313-24. PMID: 12222762
  3. Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues.  |  Sharif, NA., et al. 2003. Invest Ophthalmol Vis Sci. 44: 715-21. PMID: 12556403
  4. Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation.  |  Zhan, GL., et al. 2003. J Glaucoma. 12: 383-9. PMID: 12897587
  5. Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma.  |  Klimko, PG. and Sharif, NA. 2019. Br J Pharmacol. 176: 1051-1058. PMID: 29665040
  6. Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility.  |  Sharif, NA. and Klimko, PG. 2019. Br J Pharmacol. 176: 1059-1078. PMID: 29679483
  7. Portable exhaled breath condensate metabolomics for daily monitoring of adolescent asthma.  |  Schmidt, AJ., et al. 2020. J Breath Res. 14: 026001. PMID: 31344695

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Unoprostone isopropyl ester, 1 mg

sc-205537
1 mg
$61.00

Unoprostone isopropyl ester, 10 mg

sc-205537A
10 mg
$490.00