UNC 0224 (CAS 1197196-48-7)
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UNC 0224 is a compound of interest within the field of molecular biology and epigenetics, where it is primarily used to study the histone lysine methyltransferase G9a. By inhibiting this enzyme, UNC 0224 allows researchers to probe the role of histone methylation in the regulation of gene expression. This compound is instrumental in dissecting the complex epigenetic mechanisms that contribute to chromatin structure and function. Furthermore, UNC 0224 is employed in the study of cellular differentiation and proliferation, as G9a is known to play a role in these processes through its epigenetic regulation. The specificity of UNC 0224 for G9a over other histone methyltransferases makes it useful for scientists aiming to elucidate the selective effects of histone methylation on the genome.
UNC 0224 (CAS 1197196-48-7) References
- Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. | Rabal, O., et al. 2018. J Med Chem. 61: 6518-6545. PMID: 29953809
- Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients. | Dennison, JL., et al. 2022. Cancers (Basel). 14: PMID: 36077629
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UNC 0224, 10 mg | sc-362816 | 10 mg | $194.00 | |||
UNC 0224, 50 mg | sc-362816A | 50 mg | $816.00 |