UMPS Antibody (3H6): sc-135596
- UMPS Antibody (3H6) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant UMPS protein of human origin
- recommended for detection of UMPS of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for UMPS Antibody (3H6). This work is in progress.
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SEE ALSO...
UMPS Antibody (3H6) is a mouse monoclonal IgG2b antibody that detects uridine 5′-monophosphate synthase (UMPS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). UMPS plays a crucial role in the pyrimidine biosynthetic pathway by catalyzing the final two steps, which are essential for the synthesis of nucleotides necessary for DNA and RNA production. This enzyme is unique to eukaryotes, as UMPS combines the activities of orotate phosphoribosyltransferase and orotidine-5′-monophosphate decarboxylase into a single protein, thereby enhancing the stability of catalytic centers. Any loss of UMPS enzymatic function can lead to hereditary orotic aciduria, a rare genetic disorder that manifests as growth retardation, anemia, and increased urinary excretion of orotic acid. Additionally, the existence of two UMPS isoforms, resulting from alternative splicing, highlights the complexity of regulation and function in different cellular contexts. Anti-UMPS antibody (3H6) provides reliable detection and analysis of UMPS, serving as an invaluable tool for researchers studying nucleotide metabolism and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UMPS Antibody (3H6) | sc-135596 | 100 µg/ml | $339.00 |