Molecular structure of UMI-77, CAS Number: 518303-20-3
UMI-77 (CAS 518303-20-3)
Alternate Names:
2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid
CAS Number:
518303-20-3
Molecular Weight:
468.3
Molecular Formula:
C18H14BrNO5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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UMI-77 (CAS 518303-20-3) References
- UMI-77 primes glioma cells for TRAIL-induced apoptosis by unsequestering Bim and Bak from Mcl-1. | Liu, JW., et al. 2017. Mol Cell Biochem. 432: 55-65. PMID: 28337703
- Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. | Mallick, DJ., et al. 2019. Cell Death Dis. 10: 185. PMID: 30796196
- Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis. | Jin, L., et al. 2022. FASEB J. 36: e22342. PMID: 35524750
- Cirsiliol regulates mitophagy in colon cancer cells via STAT3 signaling. | Jiang, T., et al. 2022. Cancer Cell Int. 22: 304. PMID: 36207761
- UMI-77 Modulates the Complement Cascade Pathway and Inhibits Inflammatory Factor Storm in Sepsis Based on TMT Proteomics and Inflammation Array Glass Chip. | Xu, Y., et al. 2023. J Proteome Res. 22: 3464-3474. PMID: 37830896
- Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor. | Niu, P., et al. 2024. Bioorg Med Chem Lett. 101: 129658. PMID: 38373466
- Mitophagy defect mediates the aging-associated hallmarks in Hutchinson-Gilford progeria syndrome. | Sun, Y., et al. 2024. Aging Cell. 23: e14143. PMID: 38482753
- Prognostic Risk Models Using Epithelial Cells Identify β-Sitosterol as a Potential Therapeutic Target Against Esophageal Squamous Cell Carcinoma. | Zhang, Z., et al. 2024. Int J Gen Med. 17: 1193-1211. PMID: 38559590
- Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo. | Chen, X., et al. 2024. Eur J Pharmacol. 975: 176647. PMID: 38754534
- Hippocampal mitophagy contributes to spatial memory via maintaining neurogenesis during the development of mice. | Xu, L., et al. 2024. CNS Neurosci Ther. 30: e14800. PMID: 38887162
Inhibitor of:
Bcl-B, Bcl-G, Bcl-w, Bcl-xl, BCLP, Bclp2, Bim EL, c-IAP2, Mcl-1, Mcl-1L, MOMP, and PISD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UMI-77, 5 mg | sc-507475 | 5 mg | $130.00 |