Molecular structure of Umeclidinium Bromide, CAS Number: 869113-09-7
Umeclidinium Bromide (CAS 869113-09-7)
Alternate Names:
4-(Hydroxydiphenylmethyl)-1-[2-[(phenylmethyl)oxy]ethyl]-1-azabicyclo[2.2.2]octanium bromide
CAS Number:
869113-09-7
Molecular Weight:
508.49
Molecular Formula:
C29H34BrNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Umeclidinium is a potent antagonist of muscarinic acetylcholine receptors, specifically M1-M5 receptors (Kis = 0.05-0.16 nM). It effectively inhibits acetylcholine-induced activation of M3 receptors in CHO cells (IC50 < 10 nM). In human airway smooth muscle cells, Umeclidinium attenuates methacholine-induced calcium release (EC50 = 10 µM) and intranasal administration in mice leads to bronchoconstriction relief (ED50 = 0.02 µg). Umeclidinium bromide, a quaternary ammonium salt, acts as a muscarinic receptor antagonist in the airways, resulting in bronchodilation. By binding to muscarinic receptors, Umeclidinium bromide reduces intracellular calcium levels, leading to relaxation of airway smooth muscle cells.
Umeclidinium Bromide (CAS 869113-09-7) References
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- The Utilization and Safety of Umeclidinium and Umeclidinium/Vilanterol in UK Primary Care: A Retrospective Cohort Study. | Requena, G., et al. 2021. Int J Chron Obstruct Pulmon Dis. 16: 629-642. PMID: 33731992
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Umeclidinium Bromide, 10 mg | sc-475670 | 10 mg | $401.00 |