Date published: 2026-5-19

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Umbellulone (CAS 546-78-1)

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Alternate Names:
(−)-Umbellulone; Umbellol; Oreodaphnol
Application:
Umbellulone is a selective ANKTM1 (TRPA1) activator for proteomics research
CAS Number:
546-78-1
Molecular Weight:
150.22
Molecular Formula:
C10H14O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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oundUmbellulone, a monoterpene ketone found prominently in the essential oil of Umbellularia californica, known as the California bay laurel, exhibits a unique and intriguing mechanism of action largely explored within the realm of chemical research. Its molecular structure enables it to interact with a variety of biochemical pathways, notably acting as a potent activator of TRPA1 (transient receptor potential ankyrin 1) channels. This interaction is of significant interest in research focused on understanding the molecular basis of sensation, as TRPA1 channels are critical for the detection of environmental irritants and the mediation of inflammatory responses. Umbellulone′s ability to modulate these channels provides useful for dissecting the complexities of sensory mechanisms and the cellular response to external stimuli. Moreover, its natural occurrence and specific biochemical properties have made it a subject of study in the synthesis and development of novel comps, contributing to the expansion of knowledge in organic chemistry and the exploration of new avenues in chemical research.


Umbellulone (CAS 546-78-1) References

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  8. Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide.  |  Moldovan Loomis, C., et al. 2019. J Pharmacol Exp Ther. 369: 26-36. PMID: 30643015
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  12. Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors.  |  Woodman, SE., et al. 2022. Front Pain Res (Lausanne). 3: 809352. PMID: 35295808
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Umbellulone, 10 mg

sc-396564
10 mg
$145.00