UK 5099 is an inhibitor of the mitochondrial pyruvate carrier (MPC) and plasma membrane monocarboxylate transporters (MCTs).
1. Wiemer, E A., et al., 1995. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. The Biochemical journal. 312 ( Pt 2)(): 479-84. PMID: 8526859 2. Hildyard, John C W., et al., 2003. Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. The Biochemical journal. 374(Pt 3): 607-11. PMID: 12887330 3. Hinoi, Eiichi., et al., 2006. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Molecular pharmacology. 70(3): 925-35. PMID: 16766717
Soluble in DMSO (>20 mg/mL), and Ethyl Acetate .
Store at 4° C
448.65° C at 760 mmHg (Predicted)
1.21 g/cm3 (Predicted)
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Hinoi et alHinoi et al. (PubMed ID 16766717) used UK-5099 to block pyruvate release into DMEM medium by inhibiting bidirectional membrane movement of pyruvate via monocarboxylate transport in osteoblasts. -SCBT Publication Review
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