Molecular structure of UK 5099, CAS Number: 56396-35-1
UK 5099 (CAS 56396-35-1)
See product citations (5)
Alternate Names:
(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid
Application:
UK 5099 is an inhibitor of the mitochondrial pyruvate carrier & plasma membrane monocarboxylate transporters
CAS Number:
56396-35-1
Purity:
≥97%
Molecular Weight:
288.31
Molecular Formula:
C18H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
UK 5099 is presumed to interact with particular proteins and enzymes, thereby affecting their structure and function. As a result, cellular processes and biochemical reactions undergo modifications due to these alterations caused by the binding of UK 5099 to the proteins and enzymes.
UK 5099 (CAS 56396-35-1) References
- Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. | Hildyard, JC. and Halestrap, AP. 2003. Biochem J. 374: 607-11. PMID: 12887330
- A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. | Hinoi, E., et al. 2006. Mol Pharmacol. 70: 925-35. PMID: 16766717
- Electrophysiological actions of Ro5-4864 on cerebellar Purkinje neurons: evidence for 'peripheral' benzodiazepine receptor-mediated depression. | Basile, AS., et al. 1989. J Pharmacol Exp Ther. 248: 463-9. PMID: 2536432
- Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma. | Wilkins, LR., et al. 2017. Cardiovasc Intervent Radiol. 40: 430-437. PMID: 27872984
- Lactate is oxidized outside of the mitochondrial matrix in rodent brain. | Herbst, EAF., et al. 2018. Appl Physiol Nutr Metab. 43: 467-474. PMID: 29206478
- Properties of the principal anion-exchange mechanism in human neutrophils. | Simchowitz, L. 1988. Soc Gen Physiol Ser. 43: 193-208. PMID: 3077546
- A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. | Yamashita, Y., et al. 2020. Angew Chem Int Ed Engl. 59: 3896-3899. PMID: 31863675
- Mitochondrial Pyruvate Carriers are not Required for Adipogenesis but are Regulated by High-Fat Feeding in Brown Adipose Tissue. | Burrell, JA., et al. 2020. Obesity (Silver Spring). 28: 293-302. PMID: 31970913
- Mitochondrial pyruvate carrier as a key regulator of fever and neuroinflammation. | Guimarães, NC., et al. 2021. Brain Behav Immun. 92: 90-101. PMID: 33242651
- Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss. | Liu, X., et al. 2021. J Med Chem. 64: 2046-2063. PMID: 33534563
- Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. | Buyse, C., et al. 2021. Cancers (Basel). 13: PMID: 34503089
- Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening. | Hegazy, L., et al. 2022. Biomedicines. 10: PMID: 35203575
- Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC-MS/MS. | Zeng, Q., et al. 2022. BMC Vet Res. 18: 145. PMID: 35443692
- Cell volume regulation in human neutrophils: 2-(aminomethyl)phenols as Cl- channel inhibitors. | Simchowitz, L., et al. 1993. Am J Physiol. 265: C143-55. PMID: 8393278
- The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. | Wiemer, EA., et al. 1995. Biochem J. 312 (Pt 2): 479-84. PMID: 8526859
Inhibitor of:
γ-GCSc, CPTI-L, cytochrome b, D10Jhu81e, D10Wsu102e, DNTTIP2, EG623286, GLYATL3, IER2, Inhibitors, MAMSTR, MCT2, MPC1L, MYL4, NIPSNAP1, PDH-E1α, and PTRH2.Activator of:
PDK3, and PDK4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UK 5099, 10 mg | sc-361394 | 10 mg | $154.00 | |||
UK 5099, 50 mg | sc-361394A | 50 mg | $633.00 |