UK 5099 CAS: 56396-35-1
MF: C18H12N2O2
MW: 288.31
An inhibitor of the mitochondrial pyruvate carrier & plasma membrane monocarboxylate transporters.

UK 5099 (CAS 56396-35-1)

UK 5099 | CAS 56396-35-1 is rated 5.0 out of 5 by 1.
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Alternate Names: (E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid
Application: UK 5099 is an inhibitor of the mitochondrial pyruvate carrier & plasma membrane monocarboxylate transporters
CAS Number: 56396-35-1
Purity: ≥97%
Molecular Weight: 288.31
Molecular Formula: C18H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

UK 5099 is an inhibitor of the mitochondrial pyruvate carrier (MPC) and plasma membrane monocarboxylate transporters (MCTs).


References

1. Wiemer, E A., et al., 1995. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. The Biochemical journal. 312 ( Pt 2)(): 479-84. PMID: 8526859
2. Hildyard, John C W., et al., 2003. Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. The Biochemical journal. 374(Pt 3): 607-11. PMID: 12887330
3. Hinoi, Eiichi., et al., 2006. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Molecular pharmacology. 70(3): 925-35. PMID: 16766717

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/mL), and Ethyl Acetate .
Storage :
Store at 4° C
Melting Point :
235-238° C
Boiling Point :
448.65° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6438504
MDL Number :
MFCD19443867
SMILES :
C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)/C=C(\\C#N)/C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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UK 5099 (CAS 56396-35-1)  Product Citations

See how others have used UK 5099 (CAS 56396-35-1). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27215380  2016. Molecular and cellular biology. 36: 2089-104.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Hinoi et al Hinoi et al. (PubMed ID 16766717) used UK-5099 to block pyruvate release into DMEM medium by inhibiting bidirectional membrane movement of pyruvate via monocarboxylate transport in osteoblasts. -SCBT Publication Review
Date published: 2015-06-08
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