Molecular structure of UK 383367, CAS Number: 348622-88-8
UK 383367 (CAS 348622-88-8)
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Alternate Names:
(βR)-3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide; 5-{(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide
Application:
UK 383367 is a selective and potent inhibitor of BMP-1
CAS Number:
348622-88-8
Molecular Weight:
324.38
Molecular Formula:
C15H24N4O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UK 383367 is a selective and potent inhibitor of bone morphogenetic protein 1 (BMP-1), which is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. This compound is more than 200-fold selective for BMP1 over a panel of matrix metalloproteinases. UK 383367 is effective in a cell-based model of collagen deposition is very effective at penetrating human skin in vitro.
UK 383367 (CAS 348622-88-8) References
- Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. | Allan, GA., et al. 2006. Xenobiotica. 36: 399-418. PMID: 16854779
- Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells. | Tovar-Vidales, T., et al. 2013. Invest Ophthalmol Vis Sci. 54: 4741-8. PMID: 23788373
- Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets. | Bekhouche, M., et al. 2016. FASEB J. 30: 1741-56. PMID: 26740262
- Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients. | Hsieh, YY., et al. 2018. BMC Cancer. 18: 508. PMID: 29720137
- AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy. | Juban, G., et al. 2018. Cell Rep. 25: 2163-2176.e6. PMID: 30463013
- Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake. | Banerjee, S., et al. 2019. Sci Rep. 9: 11416. PMID: 31388055
- Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional. | Strøm, TB., et al. 2020. Hum Mol Genet. 29: 1229-1238. PMID: 31600776
- Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer. | Salcedo, EC., et al. 2021. ACS Chem Biol. 16: 712-723. PMID: 33765766
- Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases. | Molina, T., et al. 2021. Open Biol. 11: 210110. PMID: 34875199
- Delayed inhibition of collagen deposition by targeting bone morphogenetic protein 1 promotes recovery after spinal cord injury. | Huang, Y., et al. 2023. Matrix Biol. 118: 69-91. PMID: 36918086
- Lysyl oxidase-like 2 processing by factor Xa modulates its activity and substrate preference. | Wang, H., et al. 2023. Commun Biol. 6: 375. PMID: 37029269
Inhibitor of:
Enzyme, and Neprilysin-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UK 383367, 5 mg | sc-361393 | 5 mg | $115.00 | |||
UK 383367, 25 mg | sc-361393A | 25 mg | $434.00 |