Molecular structure of UK 370106, CAS Number: 230961-21-4
UK 370106 (CAS 230961-21-4)
See product citations (4)
Alternate Names:
MMP-3/MMP-12 Inhiibitor
Application:
UK 370106 is a selective inhibitor of MMP-3 and MMP-12
CAS Number:
230961-21-4
Purity:
≥95%
Molecular Weight:
572.73
Molecular Formula:
C35H44N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 amd 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively). Has little effect on keratinocyte migration in vitro and inhibits fibronectin cleavage (IC50 = 320 nM). Substantially inhibits MMP-3 in an ex-vivo model of chronic dermal ulcers.
UK 370106 (CAS 230961-21-4) References
- High-throughput and parallel screening methods in asymmetric hydrogenation. | Jäkel, C. and Paciello, R. 2006. Chem Rev. 106: 2912-42. PMID: 16836304
- A novel series of highly selective inhibitors of MMP-3. | Whitlock, GA., et al. 2007. Bioorg Med Chem Lett. 17: 6750-3. PMID: 18029177
- Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. | Matthews, KH., et al. 2008. Int J Pharm. 356: 110-20. PMID: 18280068
- Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis. | Tang, CH., et al. 2010. Biochem Pharmacol. 79: 209-17. PMID: 19682436
- Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-α in THP-1 macrophages. | Suzuki, M. and Mihara, M. 2012. Cytokine. 58: 344-50. PMID: 22424696
- Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. | Ågren, MS., et al. 2015. Eur J Cell Biol. 94: 12-21. PMID: 25457675
- Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease. | Biancheri, P., et al. 2015. Gastroenterology. 149: 1564-1574.e3. PMID: 26170138
- RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. | Li, C., et al. 2016. Nat Commun. 7: 11455. PMID: 27126736
- Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages. | Werneburg, S., et al. 2016. Glia. 64: 1314-30. PMID: 27159043
- Novel effects of sphingosylphosphorylcholine on invasion of breast cancer: Involvement of matrix metalloproteinase-3 secretion leading to WNT activation. | Kim, HJ., et al. 2016. Biochim Biophys Acta. 1862: 1533-43. PMID: 27216977
- Development and Application of the Metalloprotease Activity Multiplexed Bead-Based Immunoassay (MAMBI). | Ahrens, CC., et al. 2019. Biochemistry. 58: 3938-3942. PMID: 31474112
- Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma. | Rutland, CS., et al. 2021. Front Vet Sci. 8: 704598. PMID: 34414229
- Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein. | Yamamoto, M., et al. 2022. mBio. 13: e0051922. PMID: 35708281
- Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. | Simpson, S., et al. 2022. Front Vet Sci. 9: 965391. PMID: 36570509
Inhibitor of:
ADAMTS-6, Enzyme, MMP-12, and MMP-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UK 370106, 10 mg | sc-204375 | 10 mg | $363.00 | |||
UK 370106, 25 mg | sc-204375A | 25 mg | $700.00 |