UK 14,304 CAS: 59803-98-4
MF: C11H10BrN5
MW: 292.14
An α2-adrenergic receptor agonist.

UK 14,304 (CAS 59803-98-4)

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Alternate Names: Brimonidine; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine
Application: UK 14,304 is an α2-adrenergic receptor agonist
CAS Number: 59803-98-4
Molecular Weight: 292.14
Molecular Formula: C11H10BrN5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist. It is useful for studying the inhibition of R-type calcium currents in myenteric neurons.


References

1. Andorn, A C., et al., 1988. Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life sciences. 43(22): 1805-12. PMID: 2904634
2. MacDonald, E., et al., 1997. Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. Trends in pharmacological sciences. 18(6): 211-9. PMID: 9227000
3. Chopin, P., et al., 1999. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. The Journal of pharmacology and experimental therapeutics. 288(2): 798-804. PMID: 9918591

Physical State :
Solid
Solubility :
Soluble in ethanol (<8 mg/ml, warm), DMSO (100 mM), methanol, and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
235-236° C
Boiling Point :
~432.55° C at 760 mmHg (Predicted)
Density :
~1.8 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
IC50 :
α2-AR: IC50 = 3 nM (human); α2-AR: IC50 = 3.6 nM (rat); α2A-AR: IC50 = 298 nM (human); α2B-AR: IC50 = 1.05 µM (human); α1D-AR: IC50 = 1.72 µM (human)
Ki Data :
α2-AR: Ki= 2.4 nM (human); α2A-AR: Ki= 2.7 nM (human); α2-AR: Ki= 30 nM (rat); α2C-AR: Ki= 44 nM (human); α2B-AR: Ki= 52 nM (rat)
pK Values :
pKb: 7.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
VD1200000
PubChem CID :
2435
Merck Index :
14: 1375
MDL Number :
MFCD00153878
Beilstein Registry :
751629
SMILES :
C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br

Download SDS (MSDS)

Certificate of Analysis

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