Molecular structure of UK 14,304, CAS Number: 59803-98-4
UK 14,304 (CAS 59803-98-4)
Alternate Names:
Brimonidine; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine
Application:
UK 14,304 is an α2-adrenergic receptor agonist
CAS Number:
59803-98-4
Molecular Weight:
292.14
Molecular Formula:
C11H10BrN5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist. It is useful for studying the inhibition of R-type calcium currents in myenteric neurons. UK 14,304 exerts its effects through the activation of alpha-2 adrenergic receptors, predominantly present in the eye. This activation results in the reduction of aqueous humor production. Additionally, UK 14,304 has found extensive use in various in vitro studies, where its impact on cell lines has been thoroughly explored, encompassing areas such as cell proliferation, apoptosis, and gene expression.
UK 14,304 (CAS 59803-98-4) References
- Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304. | Cockcroft, V., et al. 2000. J Neurochem. 74: 1705-10. PMID: 10737629
- Influence of nitric oxide donors and of the alpha(2)-agonist UK-14,304 on acetylcholine release in the pig gastric fundus. | Leclere, PG. and Lefebvre, RA. 2001. Neuropharmacology. 40: 270-8. PMID: 11114406
- UK-14,304, R(-)-alpha-methyl-histamine and SMS 201-995 block plasma protein leakage within dura mater by prejunctional mechanisms. | Matsubara, T., et al. 1992. Eur J Pharmacol. 224: 145-50. PMID: 1281776
- The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. | Francis, H., et al. 2007. Am J Physiol Cell Physiol. 293: C1252-62. PMID: 17634418
- Effects of advanced glycation end products-inductor glyoxal and hydrogen peroxide as oxidative stress factors on rat retinal organ cultures and neuroprotection by UK-14,304. | Knels, L., et al. 2008. J Neurochem. 106: 1876-87. PMID: 18624919
- Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. | Andorn, AC., et al. 1988. Life Sci. 43: 1805-12. PMID: 2904634
- Repeated treatment with the α2-adrenoceptor agonist UK-14304 improves cognitive performance in middle-age rats: Role of hippocampal Fas-associated death domain. | Hernández-Hernández, E., et al. 2018. J Psychopharmacol. 32: 248-255. PMID: 29207901
- The contractions induced in rat and guinea-pig aortic strips by the alpha 2-adrenoceptor selective agonists B-HT 920 and UK 14,304 are mediated by alpha 1-adrenoceptors. | Beckeringh, JJ., et al. 1984. Eur J Pharmacol. 104: 197-203. PMID: 6149946
- Central nervous system depressant actions of clonidine and UK-14,304: partial dissociation of EEG and behavioural effects. | Ashton, H. and Rawlins, MD. 1978. Br J Clin Pharmacol. 5: 135-40. PMID: 619947
- Involvement of peripheral presynaptic inhibition in the reduction of sympathetic tone by moxonidine, rilmenidine and UK 14304. | Urban, R., et al. 1995. Eur J Pharmacol. 282: 29-37. PMID: 7498287
- Contrasting effects of the imidazol(in)e alpha 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies. | Dalley, JW. and Stanford, SC. 1995. Br J Pharmacol. 114: 1717-23. PMID: 7599940
- Gi down-regulation and heterologous desensitization in adipocytes after treatment with the alpha 2-agonist UK 14304. | Gasic, S. and Green, A. 1995. Biochem Pharmacol. 49: 785-90. PMID: 7702636
- Effects of UK-14,304, noradrenaline, and propranolol on insulin release from transplanted mouse islets. | Shi, CL., et al. 1996. Eur J Endocrinol. 135: 724-8. PMID: 9025719
- Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. | MacDonald, E., et al. 1997. Trends Pharmacol Sci. 18: 211-9. PMID: 9227000
- Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. | Chopin, P., et al. 1999. J Pharmacol Exp Ther. 288: 798-804. PMID: 9918591
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AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UK 14,304, 10 mg | sc-204373 | 10 mg | $112.00 | |||
UK 14,304, 50 mg | sc-204373A | 50 mg | $455.00 |