UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist. It is useful for studying the inhibition of R-type calcium currents in myenteric neurons.
1. Andorn, A C., et al., 1988. Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life sciences. 43(22): 1805-12. PMID: 2904634 2. MacDonald, E., et al., 1997. Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. Trends in pharmacological sciences. 18(6): 211-9. PMID: 9227000 3. Chopin, P., et al., 1999. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. The Journal of pharmacology and experimental therapeutics. 288(2): 798-804. PMID: 9918591
Soluble in ethanol (<8 mg/ml, warm), DMSO (100 mM), methanol, and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/ml). Insoluble in water.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn