UK-1 (CAS 151271-53-3)

UK-1, identified by CAS number 151271-53-3, is a benzoxazole-derived compound originally isolated from the actinomycete Streptomyces sp. This chemical is notable for its unique molecular structureUK-1, with the CAS number 151271-53-3, is an intriguing organic compound belonging to the benzoxazole family, initially isolated from the actinomycete Streptomyces sp. This molecule is characterized by a fused benzoxazole ring and a distinct polyketide side chain, which are critical for its biological activity. The primary mechanism of action of UK-1 involves its interaction with DNA, where it binds selectively to the minor groove of DNA. This binding affects the DNA′s double helix, influencing various DNA-mediated processes. In the field of research, UK-1 has been extensively used as a tool to study transcriptional regulation and DNA replication dynamics. By interfering with the normal function of DNA, researchers can investigate the role of minor groove binders in modulating genetic processes and how these interactions might be exploited to control biological outcomes. Moreover, the ability of UK-1 to bind DNA makes it a valuable compound for studying interactions between small molecules and nucleic acids, enhancing our understanding of molecular recognition processes that are fundamental to both basic biology and the development of novel research tools.