UGRP1 Antibody (1B2): sc-517117
- UGRP1 Antibody (1B2) is a mouse monoclonal IgG2a κ UGRP1 antibody provided at 100 µg/ml
- raised against amino acids 1-93 representing full length UGRP1 of human origin
- recommended for detection of UGRP1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for UGRP1 Antibody (1B2). This work is in progress.
UGRP1 Antibody (1B2) is a mouse monoclonal IgG2a kappa light chain antibody that detects the UGRP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-UGRP1 antibody (1B2) is available as a non-conjugated format. Uteroglobin-related protein 1 (UGRP1) is a 93-amino acid secretory protein predominantly expressed in lung Clara-like epithelial cells, with lower expression levels found in the thyroid. UGRP1 plays a crucial role in modulating inflammatory responses in the lungs, particularly in conditions such as allergic asthma and cystic fibrosis. UGRP1 interacts with the macrophage scavenger receptor with collagenous structure (MARCO), which may facilitate pathogen clearance in the lung environment. UGRP1 has a binding site for bacterial lipopolysaccharide (LPS), highlighting potential involvement in immune responses to bacterial infections. UGRP1 expression is downregulated in antigen-induced inflamed airways, suggesting a protective mechanism against excessive inflammation, while UGRP1 upregulation in cystic fibrosis indicates a complex role in lung pathology. Given involvement in these processes, UGRP1 may serve as a promising therapeutic target for various lung inflammatory conditions.
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UGRP1 Antibody (1B2) References:
- UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor. | Niimi, T., et al. 2001. Mol Endocrinol. 15: 2021-36. PMID: 11682631
- Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. | Bin, LH., et al. 2003. J Immunol. 171: 924-30. PMID: 12847263
- Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. | Srisodsai, A., et al. 2004. J Biol Chem. 279: 54358-68. PMID: 15485815
- Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9. | Chiba, Y., et al. 2004. Am J Physiol Lung Cell Mol Physiol. 287: L1193-8. PMID: 15531759
- Uteroglobin-related protein 1(UGRP1) gene polymorphisms and atopic asthma in the Indian population. | Batra, J., et al. 2005. Int Arch Allergy Immunol. 136: 1-6. PMID: 15591807
- Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. | Chiba, Y., et al. 2005. Immunol Lett. 97: 123-9. PMID: 15626484
- Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice. | Chiba, Y., et al. 2006. Am J Respir Crit Care Med. 173: 958-64. PMID: 16456148
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UGRP1 Antibody (1B2) | sc-517117 | 100 µg/ml | $322.00 |