UDP-GlcDH Antibody (A-9): sc-393438

UDP-GlcDH Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects UDP-GlcDH in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UDP-GlcDH, also known as UDP-glucose 6-dehydrogenase, plays a vital role in converting UDP-glucose to UDP-glucuronic acid, a key precursor in the biosynthesis of glycosaminoglycans, including hyaluronan, heparan sulfate, and chondroitin sulfate. These glycosaminoglycans are essential components of the extracellular matrix, contributing significantly to processes such as signal transduction, cell migration, and cancer progression. UDP-GlcDH functions in the liver, where UDP-glucuronic acid is crucial for the detoxification and excretion of harmful compounds. Structurally, UDP-GlcDH exists as a homohexamer, a configuration highly conserved across various species, demonstrating 97% sequence identity among different mammalian species. Expression of UDP-GlcDH is regulated by factors such as TGFβ, which upregulates expression, and hypoxia, which downregulates expression, highlighting UDP-GlcDH′s potential role in cellular responses to environmental changes. With broad reactivity and critical biological functions, anti-UDP-GlcDH antibody (A-9) serves as an invaluable tool for researchers studying metabolic pathways and disease mechanisms.

The preferred UDP-GlcDH antibody is UDP-GlcDH Antibody (B-4): sc-137058.