Molecular structure of UDP disodium salt, CAS Number: 27821-45-0
UDP disodium salt (CAS 27821-45-0)
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Alternate Names:
Uridine-5′-diphosphate disodium salt
Application:
UDP disodium salt is a P2Y6 receptor agonist and GPR105 receptor inhibitor
CAS Number:
27821-45-0
Purity:
≥97%
Molecular Weight:
448.12
Molecular Formula:
C9H12N2O12P2•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UDP disodium salt is an endogenous P2Y receptor agonist, which specifically activates P2Y6 receptors. It is known that UDP disodium salt can also function as a competitive antagonist at GPR105 (P2Y14) receptors. UDP disodium salt is composed of a pyrophosphate, ribose, and a uracil group, with the pyrophosphate esterified to the C5 of the sugar moiety. P2Y receptors are G-protein coupled receptors which are activated by nucleotides, with P2Y6 known to interact specifically with UDP, ADP, and UTP. Studies suggest that P2Y6 is an important component in activating p38 MAPK-mediated COX-2 expression.
UDP disodium salt (CAS 27821-45-0) References
- UDP is a competitive antagonist at the human P2Y14 receptor. | Fricks, IP., et al. 2008. J Pharmacol Exp Ther. 325: 588-94. PMID: 18252808
- UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an epidermal growth factor receptor-transregulated mechanism. | Norambuena, A., et al. 2010. J Biol Chem. 285: 2940-50. PMID: 19996104
- One-step synthesis of novel glycosyltransferase inhibitors. | Evitt, A., et al. 2012. Chem Commun (Camb). 48: 11856-8. PMID: 23125983
- Artificial Fusion of mCherry Enhances Trehalose Transferase Solubility and Stability. | Mestrom, L., et al. 2019. Appl Environ Microbiol. 85: PMID: 30737350
- Spatiotemporal control of coacervate formation within liposomes. | Deshpande, S., et al. 2019. Nat Commun. 10: 1800. PMID: 30996302
- Nonspherical Coacervate Shapes in an Enzyme-Driven Active System. | Spoelstra, WK., et al. 2020. Langmuir. 36: 1956-1964. PMID: 31995710
- pH-Controlled Coacervate-Membrane Interactions within Liposomes. | Last, MGF., et al. 2020. ACS Nano. 14: 4487-4498. PMID: 32239914
- Purinergic signaling in peripheral nervous system glial cells. | Patritti-Cram, J., et al. 2021. Glia. 69: 1837-1851. PMID: 33507559
- Selective β-Mono-Glycosylation of a C15-Hydroxylated Metabolite of the Agricultural Herbicide Cinmethylin Using Leloir Glycosyltransferases. | Jung, J., et al. 2021. J Agric Food Chem. 69: 5491-5499. PMID: 33973475
- Safety evaluation of steviol glycoside preparations, including rebaudioside AM, obtained by enzymatic bioconversion of highly purified stevioside and/or rebaudioside A stevia leaf extracts. | , ., et al. 2021. EFSA J. 19: e06691. PMID: 34377189
- A purinergic mechanism underlying metformin regulation of hyperglycemia. | Senfeld, J., et al. 2023. iScience. 26: 106898. PMID: 37378329
- Partial purification and kinetics of oestriol 16 alpha-glucuronyltransferase from the cytosol fraction of human liver. | Rao, GS., et al. 1970. Biochem J. 118: 625-34. PMID: 5481497
- Receptors for purines and pyrimidines. | Ralevic, V. and Burnstock, G. 1998. Pharmacol Rev. 50: 413-92. PMID: 9755289
Inhibitor of:
GPR105.Activator of:
P2Y6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UDP disodium salt, 50 mg | sc-204372 | 50 mg | $57.00 |