Molecular structure of UCN-02, CAS Number: 121569-61-7
UCN-02 (CAS 121569-61-7)
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Application:
UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture
CAS Number:
121569-61-7
Purity:
>98%
Molecular Weight:
482.50
Molecular Formula:
C28H26N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antibiotic UCN-02 is a indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.
UCN-02 (CAS 121569-61-7) References
- UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century? | Akinaga, S., et al. 2000. Anticancer Drug Des. 15: 43-52. PMID: 10888035
- UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway. | Facchinetti, MM., et al. 2004. Cancer Res. 64: 3629-37. PMID: 15150122
- UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. | Takahashi, I., et al. 1989. J Antibiot (Tokyo). 42: 571-6. PMID: 2656615
- UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. | Takahashi, I., et al. 1989. J Antibiot (Tokyo). 42: 564-70. PMID: 2722672
Inhibitor of:
cPKC γ, PKC beta, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCN-02, 500 µg | sc-202377 | 500 µg | $220.00 | |||
UCN-02, 1 mg | sc-202377A | 1 mg | $400.00 | |||
UCN-02, 5 mg | sc-202377B | 5 mg | $1600.00 |