UCN-02 CAS: 121569-61-7
MF: C28H26N4O4
MW: 482.5

UCN-02 (CAS 121569-61-7)

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Application: UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture
CAS Number: 121569-61-7
Purity: >98%
Molecular Weight: 482.5
Molecular Formula: C28H26N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

UCN-02 is a indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-02 is isolated as a minor co-metabolite of high staurosporine-producing strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. UCN-02 is an inhibitor of PKC α, PKC β, PKC δ, PKCε and PKC γ.


References

1. Facchinetti M.M., et al. 2004. Cancer Res. 64: 3629-3637. PMID: 15150122
2. Akinaga S., et al. 2000. Anticancer Drug Des. 15: 43-52. PMID: 10888035
3. Takahashi I., et al. 1989. J. Antibiot. 42: 571-576. PMID: 2656615

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO, ethanol, ethyl acetate, and DMF.
Storage :
Store at -20° C
Melting Point :
314.42° C (Predicted)
Boiling Point :
705.741° C at 760 mmHg (Predicted)
Density :
1.63 g/cm3 (Predicted)
Refractive Index :
n20D 1.83 (Predicted)
IC50 :
PKCα: IC50 = 0.53 µM; PKCβ: IC50 = 0.7 µM; PKCγ: IC50 = 0.39 µM; PKCδ: IC50 = 2.83 µM; PKCε: IC50 = 1.23 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3078519
SMILES :
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC

Download SDS (MSDS)

Certificate of Analysis

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UCN-02 (CAS 121569-61-7)  Product Citations

See how others have used UCN-02 (CAS 121569-61-7). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27805006  Maekawa, M. et al. 2016. Sci Rep. 6: 35762.

Citations 1 to 1 of 1 total
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