UCMA Antibody (H-2): sc-515468

UCMA Antibody (H-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects Unique cartilage matrix-associated protein (UCMA) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-UCMA antibody (H-2) is available as the non-conjugated isotype antibody. UCMA, a 138 amino acid secreted protein, plays a crucial role in the early phase of chondrocyte differentiation, being highly expressed in resting chondrocytes within developing long bones. UCMA undergoes post-translational modification by a furin-like protease, which cleaves UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, known as the Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). This modification is significant as recombinant Ucma-C interferes with the osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts, and primary osteoblasts, indicating UCMA may play a vital role in the negative regulation of osteogenic differentiation at the cartilage-bone interface and in the peripheral zones of fetal cartilage. UCMA′s ability to modulate these processes highlights UCMA′s importance in skeletal development and potential implications in bone-related disorders.

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UCMA Antibody (H-2) References:

1. Bone morphogenetic proteins.  |  Chen, D., et al. 2004. Growth Factors. 22: 233-41. PMID: 15621726
2. Endochondral ossification: how cartilage is converted into bone in the developing skeleton.  |  Mackie, EJ., et al. 2008. Int J Biochem Cell Biol. 40: 46-62. PMID: 17659995
3. Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes.  |  Tagariello, A., et al. 2008. Matrix Biol. 27: 3-11. PMID: 17707622
4. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation.  |  Adams, SL., et al. 2007. J Cell Physiol. 213: 635-41. PMID: 17886256
5. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis.  |  Surmann-Schmitt, C., et al. 2008. J Biol Chem. 283: 7082-93. PMID: 18156182
6. Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.  |  Le Jeune, M., et al. 2010. Exp Cell Res. 316: 203-15. PMID: 19819238

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UCMA Antibody (H-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UCMA Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UCMA Antibody (H-2) Specifications

Alternate Product Name: UCMA

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 47-138

Epitope Target: UCMA

Epitope Species: human

Product Reactivity/Detection: UCMA

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UCMA Antibody (H-2): N/A