Molecular structure of UCM 707, CAS Number: 390824-20-1
UCM 707 (CAS 390824-20-1)
See product citations (9)
Application:
UCM 707 is a selective inhibitor of anandamide uptake
CAS Number:
390824-20-1
Purity:
>98%
Molecular Weight:
383.57
Molecular Formula:
C25H37NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UCM 707 is a potent and selective anandamide uptake inhibitor (neuronal (C6 glioma cells): IC50=25 μM; non-neuronal (rat RBL-2H3 cells): IC50=41μM) with low affinity to CB1 receptor (CB1: Ki=4.8 μM; CB2: Ki=0.067 μM). Inhibits VR1(TRPV1) (Ki>5 μM) and FAAH (IC50 >100 μM).
UCM 707 (CAS 390824-20-1) References
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors: M.L. Lopez-Rodriguez, et al.; J. Med. Chem. 44, 4505 (2001) UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide: E. de Lago, et al.; Eur. J. Pharmacol. 449, 99 (2002) Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors: M.L. Lopez-Rodriguez, et al.; Eur. J. Med. Chem. 38, 403 (2003) Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase: M.L. Lopez-Rodriguez, et al.; J. Med. Chem. 46, 1512 (2003) Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis-a difficult issue to handle: C.J. Fowler, et al.; Eur. J. Pharmacol. 492, 1 (2004)Inhibitor of:
FAAH, and VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCM 707, 5 mg | sc-203308 | 5 mg | $120.00 | |||
UCM 707, 50 mg | sc-203308A | 50 mg | $781.00 |