UCK1 Antibody (E-9): sc-373940

UCK1 Antibody (E-9) is a mouse monoclonal IgM antibody that detects UCK1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-UCK1 antibody (E-9) is available as the non-conjugated form. UCK1, or uridine-cytidine kinase 1, plays a crucial role in the phosphorylation of uridine and cytidine, converting them into their respective monophosphates, which is essential for nucleotide metabolism and cellular energy homeostasis. This enzymatic activity is particularly important in cancer treatment, as UCK1 facilitates the activation of nucleoside analogs used in chemotherapy, thereby enhancing therapeutic efficacy. UCK1 is predominantly expressed in skeletal muscle, heart, liver, and kidney, highlighting its significance in various physiological processes. Additionally, UCK1 exists as two alternatively spliced isoforms, encoded by a gene located on human chromosome 9, indicating complex regulation of function. With 92% amino acid identity between human and mouse UCK1, conservation across species underscores its fundamental biological role. UCK1 (E-9) antibody is an invaluable tool for researchers studying nucleotide metabolism and molecular mechanisms underlying cancer therapies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

UCK1 Antibody (E-9) References:

1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.  |  Van Rompay, AR., et al. 2001. Mol Pharmacol. 59: 1181-6. PMID: 11306702
2. Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2.  |  Shimamoto, Y., et al. 2002. Jpn J Cancer Res. 93: 825-33. PMID: 12149149
3. Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2.  |  Suzuki, NN., et al. 2003. Acta Crystallogr D Biol Crystallogr. 59: 1477-8. PMID: 12876357
4. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase.  |  Suzuki, NN., et al. 2004. Structure. 12: 751-64. PMID: 15130468
5. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides.  |  Murata, D., et al. 2004. Drug Metab Dispos. 32: 1178-82. PMID: 15280220
6. Target genes of the developmental regulator PRIB of the mushroom Lentinula edodes.  |  Miyazaki, Y., et al. 2004. Biosci Biotechnol Biochem. 68: 1898-905. PMID: 15388965
7. Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels.  |  Aldenhoven, J., et al. 2006. Cytogenet Genome Res. 112: 341F. PMID: 16484797
8. Cloning, sequence analysis and expression of the basidiomycete Lentinus edodes gene uck1, encoding UMP-CMP kinase, the homologue of Saccharomyces cerevisae URA6 gene.  |  Kaneko, S., et al. 1998. Gene. 211: 259-66. PMID: 9602145

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UCK1 Antibody (E-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UCK1 Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UCK1 Antibody (E-9) Specifications

Alternate Product Name: UCK1

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1-27

Epitope Target: UCK1

Epitope Species: mouse

Product Reactivity/Detection: UCK1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UCK1 Antibody (E-9): P: Blocking Peptide