UCH-L3 Inhibitor (CAS 30675-13-9)

UCH-L3 Inhibitor is a targeted small molecule that specifically inhibits the activity of ubiquitin carboxy-terminal hydrolase L3 (UCH-L3). UCH-L3 is one of the enzymes involved in the processing of ubiquitin precursors as well as in the recycling of ubiquitin from degraded proteins, which is crucial for maintaining cellular protein homeostasis. The enzyme′s role extends to the regulation of protein degradation pathways that are essential for cell cycle progression, signal transduction, and stress response. The mechanism by which the UCH-L3 Inhibitor operates involves the blockade of the enzyme′s active site, preventing it from cleaving ubiquitin from substrate proteins. This action results in the modulation of the ubiquitin-proteasome system, leading to altered levels of protein ubiquitination and thus affecting protein turnover in cells. By inhibiting UCH-L3, researchers can study the impact of disrupted ubiquitin recycling on cellular processes, providing insights into the physiological and pathological roles of ubiquitin homeostasis.