UBTFL1/3/5/6 Antibody (F-4): sc-398786

UBTFL1/3/5/6 Antibody (F-4) is a mouse monoclonal IgG3 kappa light chain antibody that detects UBTFL1, UBTFL3, UBTFL5, and UBTFL6 of human origin, as well as UBTFL1 of mouse and rat origin, by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-UBTFL1/3/5/6 antibody (F-4) is available as a non-conjugated format. The UBTFL protein family, including UBTFL1, UBTFL3, and UBTFL6, plays a crucial role in regulating ribosomal RNA gene transcription, which is essential for ribosome biogenesis and protein synthesis in cells. UBTFL proteins are primarily located in the nucleus, where they participate in DNA-dependent processes such as transcription, replication, and repair. Two HMG box DNA-binding domains in each UBTFL protein suggest involvement in chromatin remodeling, which is vital for transcription machinery accessibility to DNA. UBTFL proteins ensure efficient ribosomal RNA gene transcription by facilitating proper chromatin configuration, supporting cellular growth and proliferation. UBTFL1/3/5/6 (F-4) antibody serves as an invaluable tool for researchers studying ribosome biogenesis and its implications in various biological processes and diseases.

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UBTFL1/3/5/6 Antibody (F-4) References:

1. Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition.  |  Weiss, MA. 2001. Mol Endocrinol. 15: 353-62. PMID: 11222737
2. HMG1 and 2: architectural DNA-binding proteins.  |  Thomas, JO. 2001. Biochem Soc Trans. 29: 395-401. PMID: 11497996
3. Recognition and repair of DNA-cisplatin adducts.  |  Woźniak, K. and Błasiak, J. 2002. Acta Biochim Pol. 49: 583-96. PMID: 12422229
4. The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation.  |  Voit, R., et al. 1992. EMBO J. 11: 2211-8. PMID: 1600946
5. The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins.  |  Stros, M., et al. 2007. Cell Mol Life Sci. 64: 2590-606. PMID: 17599239
6. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.  |  Yamada, M., et al. 2010. Hum Mol Genet. 19: 480-93. PMID: 19915186
7. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.  |  Jantzen, HM., et al. 1990. Nature. 344: 830-6. PMID: 2330041
8. CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis.  |  Suzuki, S., et al. 2015. Development. 142: 2375-84. PMID: 26092847
9. Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.  |  Umeda, M., et al. 2022. Blood Cancer Discov. 3: 194-207. PMID: 35176137
10. Overcoming the H4K20me3 epigenetic barrier improves somatic cell nuclear transfer reprogramming efficiency in mice.  |  Liu, Z., et al. 2024. Cell Prolif. 57: e13519. PMID: 37322828
11. Localization of the human RNA polymerase I transcription factor gene (UBTF) to the D17S183 locus on chromosome 17q21 and construction of a long-range restriction map of the region.  |  Jones, KA., et al. 1995. Genomics. 30: 602-4. PMID: 8825649
12. Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping.  |  Matera, AG., et al. 1997. Genomics. 41: 135-8. PMID: 9126496

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UBTFL1/3/5/6 Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UBTFL1/3/5/6 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UBTFL1/3/5/6 Antibody (F-4) Specifications

Alternate Product Name: UBTFL1/3/5/6

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 109-138

Epitope Target: UBTFL1

Epitope Species: human

Product Reactivity/Detection: UBTFL1, UBTFL3, UBTFL5 and UBTFL6 of human origin, and UBTFL1 of mouse and rat origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UBTFL1/3/5/6 Antibody (F-4): P: Blocking Peptide, X: TransCruz Reagent