Molecular structure of UBP1112, CAS Number: 339526-74-8
UBP1112 (CAS 339526-74-8)
See product citations (2)
Alternate Names:
α-Methyl-3-methyl-4-phosphonophenylglycine
Application:
UBP1112 is a potent group III mGluR antagonist
CAS Number:
339526-74-8
Purity:
≥99%
Molecular Weight:
259.2
Molecular Formula:
C10H14NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
UBP1112, is a versatile small molecule extensively employed in scientific research. This compound is classified as a phosphonate ester derived from propionic acid, making it an invaluable tool for investigating the effects of phosphonates in biological systems. UBP1112 has been widely utilized to explore various aspects of protein-protein interactions, enzyme kinetics, and signal transduction pathways. UBP1112 operates as an inhibitor, targeting specific enzymes and proteins engaged in cellular metabolism. By binding to these enzymes and proteins, it hinders their ability to catalyze their customary reactions. This inhibition, in turn, can lead to alterations in metabolite levels within the cell.
UBP1112 (CAS 339526-74-8) References
- Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. | Miller, JC., et al. 2003. Br J Pharmacol. 139: 1523-31. PMID: 12922940
- Enhanced group III mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala. | Han, JS., et al. 2004. Neuropharmacology. 46: 918-26. PMID: 15081788
- Modulation of excitatory synaptic transmission by endogenous glutamate acting on presynaptic group II mGluRs in rat substantia nigra compacta. | Wang, L., et al. 2005. J Neurosci Res. 82: 778-87. PMID: 16273546
- Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. | Li, W. and Neugebauer, V. 2006. J Neurophysiol. 96: 1803-15. PMID: 16760343
- Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors. | Carlton, SM., et al. 2011. J Neurosci. 31: 12727-37. PMID: 21900552
- Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. | Govea, RM., et al. 2012. Neuroscience. 217: 130-9. PMID: 22609935
- The role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chicken. | Mortezaei, SS., et al. 2013. Vet Res Commun. 37: 303-10. PMID: 24006087
- Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors. | Keyshams, N., et al. 2016. Vet Res Commun. 40: 63-71. PMID: 27000110
- Modulatory function of NMDA glutamate receptor on MC3/MC4 receptors agonist-induced hypophagia in neonatal meat-type chicken. | Ahmadi, F., et al. 2017. Vet Res Commun. 41: 241-248. PMID: 28589422
- Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. | Jantas, D., et al. 2018. Basic Clin Pharmacol Toxicol. 123: 443-451. PMID: 29753314
- Interaction between leptin and glutamatergic system on food intake regulation in neonatal chicken: role of NMDA and AMPA receptors. | Adeli, A., et al. 2020. Int J Neurosci. 130: 713-721. PMID: 31813315
- Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens. | Mobarhan Fard, M., et al. 2021. Arch Razi Inst. 76: 537-551. PMID: 34824747
- Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens. | Jelokhani, M., et al. 2022. Arch Razi Inst. 77: 681-688. PMID: 36284938
Inhibitor of:
mGluR-4, mGluR-6, mGluR-7, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UBP1112, 10 mg | sc-204368 | 10 mg | $686.00 | |||
UBP1112, 50 mg | sc-204368A | 50 mg | $1509.00 |