UBP 296 (CAS 745055-86-1)

UBP 296 is a potent and selective GluR5-subunit containing kainate receptor antagonist (apparent KD = 1.09 mM). It displays ~ 90-fold selectivity over both AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors and shows little to no action at NMDA or group I mGlu receptors. UBP 296 selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. UBP 296 garners significant interest owing to its potential applications across diverse scientific domains. This compound, derived from benzoic acid, comprises a pair of carboxylic groups alongside an amine group. Researchers have meticulously examined this compound for its physiological and biochemical impacts, as well as its promising roles in advancing scientific investigations. The precise mode of action of UBP 296 remains partially elusive. Nonetheless, it is postulated that the compound functions as a chelating agent, forming complexes with metal ions, thereby hampering the enzymatic and protein activities.