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Cell-permeable cross-conjugated alpha,beta-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 15.65 and 16.23 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway, selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ubiquitin Isopeptidase Inhibitor II, F6, 10 mg | sc-296678 | 10 mg | $88.00 |