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Ubiquitin Isopeptidase Inhibitor II, F6 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 15.65 and 16.23 μM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway, selectively inhibiting USP (ubiquitin isopeptidase) activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6.
Aleo, E., et al. 2006. Cancer Res. 66, 9235.
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